Results 101 to 110 of about 264,861 (313)

Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.

Cancer Research, 2018
Translocations of retinoic acid receptor-α (RARA), typically PML-RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without RARA ...
T. Osumi, Shin-ichi Tsujimoto, Moe Tamura, Meri Uchiyama, K. Nakabayashi, K. Okamura, Masanori Yoshida, D. Tomizawa, A. Watanabe, Hiroyuki Takahashi, T. Hori, Shohei Yamamoto, K. Hamamoto, M. Migita, Hiroko Ogata-Kawata, T. Uchiyama, Hiroe Kizawa, Hitomi Ueno-Yokohata, Ryota Shirai, M. Seki, K. Ohki, J. Takita, T. Inukai, S. Ogawa, T. Kitamura, Kimikazu Matsumoto, K. Hata, N. Kiyokawa, S. Goyama, Motohiro Kato   +29 more
semanticscholar   +1 more source

Misleading acute promyelocytic leukemia morphology [PDF]

Blood, 2015
![Figure][1] An 85-year-old man was admitted with a 4-week history of weakness, vertigo, weight loss, and pallor. Blood cell count showed 3 × 109/L leukocytes, 9 g/dL hemoglobin, 49 × 109/L platelets, and no disseminated intravascular coagulation.
Soraya, Wuillème, Yannick, Le Bris
openaire   +2 more sources

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation

VIEW, EarlyView.
SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Zhehan Hu, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun   +11 more
wiley   +1 more source

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Beech, Bernardi, Boisvert, Brand, Condemine, Condemine, Cuchet, Cuchet-Lourenço, de Thé, Fogal, Geng, Geoffroy, Hattersley, Hu, Ishov, Jeanne, Jensen, Jul-Larsen, Kamitani, Koken, Lallemand-Breitenbach, Lallemand-Breitenbach, Lallemand-Breitenbach, Lang, Lång, Maroui, Mathews, Negorev, Powell, Tatham, Weidtkamp-Peters, Weisshaar, Xu, Yu, Zhu   +34 more
core   +4 more sources

Venetoclax combined with cladribine, idarubicin, cytarabine (CLIA‐VEN) results in higher remission rates over conventional 7 + 3 chemotherapy without increased toxicity in newly diagnosed acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Induction chemotherapy in fit de novo acute myeloid leukaemia (AML) patients has historically combined an anthracycline with standard‐dose cytarabine (‘7 + 3’) despite complete response (CR) rates of 50%–70%. In May 2023, our institution adopted the utilization of cladribine, cytarabine, idarubicin and venetoclax (CLIA‐VEN) for intensive ...
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Anthony Quach, Yujiao Sun, Piyatida Chumnumsiriwath, Stefan O. Ciurea, Jorge Ramos‐Perez, Polina Bellman, Deepa Jeyakumar, Piyanuch Kongtim, Kiran Naqvi   +11 more
wiley   +1 more source

All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis

Leukemia Research Reports, 2018
A 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-
Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. Wang   +4 more
doaj   +1 more source

The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]

, 2001
Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Carrara, P, de Sousa, AB, Diamond, J, Foroni, L, Gameiro, P, Guimaraes, JE, Hoffbrand, AV, Mehta, AB, Parreira, A, Prentice, HG, Silva, AL, Vieira, S   +11 more
core  

Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro [PDF]

, 2015
© 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing ...
Gizelska, Katarzyna, Hoffman, Ewelina A, Mielicki, Wojciech, Mirowski, Marek   +3 more
core   +2 more sources

Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations

Clinical Case Reports, 2017
Key Clinical Message Promyelocytic leukemia is a known medical emergency and requires rapid diagnosis and expedient therapy with differentiating agents.
Sameer Sawhney, Noa G. Holtzman, Derik L. Davis, Hannah Kaizer, Victoria Giffi, Ashkan Emadi, Rima Koka   +6 more
doaj   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source