Results 61 to 70 of about 87,305 (225)

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

Patient-specific optimization of mechanical ventilation for patients with acute respiratory distress syndrome using quasi-static pulmonary P-V data

Informatics in Medicine Unlocked, 2018
Quasi-static, pulmonary pressure-volume (P-V) curves were combined with a respiratory system model to analyze tidal pressure cycles, simulating mechanical ventilation of patients with acute respiratory distress syndrome (ARDS).
Mohsen Nabian, Uichiro Narusawa
doaj   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Unilateral pulmonary artery agenesis: An unusual cause of unilateral ARDS

Respiratory Medicine Case Reports, 2018
Unilateral pulmonary artery agenesis (UPAA) is a rare malformation that can present as an isolated anomaly or may be associated with certain congenital cardiac anomalies, such as tetralogy of Fallot, atrial septal defect, coarctation of aorta, right ...
Lakshmi Saladi, MD, Swati Roy, MD, Gilda Diaz-Fuentes, MD, FCCP   +2 more
doaj   +1 more source

ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

The Professional Medical Journal, 2006
Objectives: .To assess the safety, potential efficacy, morbidity andmortality of a small tidal volume mechanical ventilation strategy designed to reduce stretch induced lung injury in ARDS.Design: A prospective interventional experimental Setting: CMH Rawalpindi:..Period: .1st Sept 2001 to 30th June2002.
openaire   +2 more sources

Ginsenoside Rg1 Ameliorates LPS‐Induced Sepsis‐Associated Lung Injury in Mice via VEGFC/D‐VEGFR3 Signaling‐Mediated Lymphangiogenesis and Lymphatic Remodeling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang, Lan Hu, Chun‐Pan Zhang, Wen‐Jie Qi, Yu‐Guo Song   +4 more
wiley   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

A Scoping Review of Laryngeal Edema Rating Scales for Extubated Acute Respiratory Failure Survivors

The Laryngoscope, EarlyView.
This scoping review identified existing laryngeal edema rating scales and evaluated whether any are adequately designed for post‐extubation acute respiratory failure (ARF) survivors. Across 35 included studies, most used subjective binary classifications and only the RTOG and Patterson Edema scales had operational definitions and reliability/validity ...
Lalita Sabat, Winston Liu, Michael H. Ieong, Lauren F. Tracy, Gintas P. Krisciunas   +4 more
wiley   +1 more source

Acute respiratory distress syndrome (ARDS) phenotyping [PDF]

Intensive Care Medicine, 2018
M. Shankar-Hari, E. Fan, N. D. Ferguson
openaire   +4 more sources