Results 131 to 140 of about 4,307,190 (305)

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Arvi pattern in the Northwest federal district during the COVID-19 pandemic (2021–2022)

Инфекция и иммунитет
Acute respiratory viral infections still remain a pressing health problem, causing both seasonal outbreaks and epidemics and global pandemics. The emergence of a new coronavirus infection has become a serious challenge, resulting in more than 776 million
A. A. Sharova, Valeriya A. Sbarzaglia, A. S. Gladkikh, D. M. Milichkina, A. V. Bachevskaya, М. R. Popova, E. A. Cherepanova, V. G. Dedkov, A. A. Totolian   +8 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

COVID-19 Across Pandemic Variant Periods: The Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study

Critical Care Explorations
IMPORTANCE:. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has evolved through multiple phases in the United States, with significant differences in patient centered outcomes with improvements in hospital strain, medical ...
Vikramjit Mukherjee, MD, FRCP, Radu Postelnicu, MD, Chelsie Parker, MS, Patrick S. Rivers, PhD, George L. Anesi, MD, MSCE, MBE, Adair Andrews, RN, MATD, Erin Ables, MA, Eric D. Morrell, MD, MA, David M. Brett-Major, MD, MPH, M. Jana Broadhurst, MD, PhD, J. Perren Cobb, MD, Amy Irwin, DNP, RN, Christopher J. Kratochvil, MD, Kelsey Krolikowski, BA, Vishakha K. Kumar, MD, MBA, Douglas P. Landsittel, PhD, Richard A. Lee, MD, Janice M. Liebler, MD, Leopoldo N. Segal, MD, Jonathan E. Sevransky, MD, MHS, Avantika Srivastava, MS, Timothy M. Uyeki, MD, MPH, Mark M. Wurfel, MD, PhD, David Wyles, MD, Laura E. Evans, MD, MSc, Karen Lutrick, PhD, Pavan K. Bhatraju, MD, MSc, on behalf of the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group   +27 more
doaj   +1 more source

Acute respiratory viral infection: challenges of diagnosis and treatment

, 2013
One of the most important features of acute respiratory viral infection (ARVI) is the continuous increase in the prevalence and proportion of this disease in the structure of human pathology today.
E. V. Nosulya
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

[The diagnosis of acute pneumonia in respiratory viral infections].

Likars'ka sprava, 1992
Data are reported of 582 case records of patients with acute pneumonia of different influenza epidemic periods, results of a study of 175 lethal cases due to acute pneumonia, that complicated influenza in adults as well as experimental studies on reproduction of para-influenzal-staphylococcal, influenzal-Klebsiella and Proteus-influenzal infections ...
E K, Trinus, Iu A, Barshteĭn, A A, Rudenko, A V, Shapiro   +3 more
openaire   +1 more source