Results 121 to 130 of about 4,307,190 (305)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Acute respiratory infection - Viral multiplication cycle

, 2011
Educação Superior::Ciências da Saúde::EnfermagemEducação Superior::Ciências da Saúde::MedicinaCovers aspects of acute respiratory infections (ARI) in young children in developing ...
Topics in International Health Acute Respiratory Infection CD-ROM, The Wellcome Trust
core   +1 more source

The Role of L-Arginine and Liposomal Vitamin C Supplementation as an Adjunct in Seasonal Respiratory Viral Infection Recovery

Advances in Respiratory Medicine
Respiratory seasonal viral infections remain one of the most important issues in community medicine. The heterogeneity of etiological agents and the characteristics of the hosts airway antiviral defenses account for the complex management of these ...
Valentina Trimarco, Paola Gallo, Seyedali Ghazihosseini, Alessia Izzo, Paola Ida Rozza, Alessandra Spinelli, Stefano Cristiano, Carlo De Rosa, Felicia Rozza, Carmine Morisco   +9 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Average proportions of viral etiologies for hospitalized acute lower respiratory infection patients in 2009–2013 by age group.

, 2014
Average proportions of viral etiologies for hospitalized acute lower respiratory infection patients in 2009–2013 by age group.
Zhongjie Li (316954), Shengjie Lai (319023), Hongjie Yu (16137), Wenbo Xu (148718), Mengfeng Li (151387), Wei Liu (20030), Honglong Zhang (447578), Harish Nair (204217), Yu Chen (29959), Luzhao Feng (376868), Zhuo Zhao (476965), Shiwen Zhao (245436), Weizhong Yang (16134), Lili Ren (174380), Xinhua Wang (286425), Jianguo Wu (30201), Zhenghong Yuan (12153), Daniel Feikin (580654), Xianfei Ye (580653), Fu Li (446847), Sa Li (298871)   +20 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Does influenza vaccination status change physician ordering patterns for respiratory viral panels? Inspection for selection bias

Human Vaccines & Immunotherapeutics, 2019
Purpose: Hospitalized patients with an acute respiratory illness (ARI) were compared to determine if demographic characteristics, timing or influenza vaccination biased who received clinical respiratory viral panel (RVP) testing.
G.K. Balasubramani, Sean Saul, Mary Patricia Nowalk, Donald B. Middleton, Jill M. Ferdinands, Richard K. Zimmerman   +5 more
doaj   +1 more source

Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction

, 2015
Amrita DosanjhDepartment of Pediatrics, Rady Children’s Hospital, San Diego, CA, USABackground: Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at
Dosanjh A
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Characteristics and Outcomes of Patients with Pulmonary Acute Respiratory Distress Syndrome Infected with Influenza versus Other Respiratory Viruses

Tuberculosis and Respiratory Diseases, 2019
Background Although the frequency of respiratory viral infection in patients with pulmonary acute respiratory distress syndrome (ARDS) is not uncommon, clinical significance of the condition remains to be further elucidated.
Jung-Wan Yoo, M.D., Sunmi Ju, M.D., Seung Jun Lee, M.D., Ph.D., Min-Chul Cho, M.D., Ph.D., Yu Ji Cho, M.D., Ph.D., Yi Yeong Jeong, M.D., Ph.D., Jong Deog Lee, M.D., Ph.D., Ho Choel Kim, M.D., Ph.D.   +7 more
doaj