Results 121 to 130 of about 27,818 (259)

Sinapic Acid Reduces Hypoxia‐Induced Cell Damage in Hep‐2 Cells by Regulating TRPM2 Channel Activation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Schematic representation of the protective effect of SPA against HPX‐induced OS, TRPM2 activation, Ca2+ overload, and apoptosis in Hep‐2 cells. ABSTRACT Hypoxia (HPX) is a significant pathological factor that contributes to mitochondrial dysfunction, oxidative stress, inflammation, and calcium dysregulation in laryngeal squamous cell carcinoma (LSCC ...
Halil İbrahim Altıner, Tarık Yağcı, Ramazan Çınar, Kenan Yıldızhan   +3 more
wiley   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Acute Retinal Necrosis [PDF]

Ophthalmology, 2010
Roger Wong, Carlos E. Pavesio, D. Alistair H. Laidlaw, Tom H. Williamson, Elizabeth M. Graham, Miles R. Stanford   +5 more
openaire   +2 more sources

Acute Retinal Necrosis and Progressive Outer Retinal Necrosis

, 2019
Necrotizing retinopathies, including acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), are a group of uncommon posterior segment complications associated with infections caused by the herpes virus. ARN was first described in 1971 by Urayama et al., Japanese ophthalmologists who termed the condition as Kirisawa uveitis and ...
Atsunobu Takeda, Mitsuru Arima, Keijiro Ishikawa, Eiichi Hasegawa, Yusuke Murakami, Koh-Hei Sonoda   +5 more
openaire   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Association of Herpes Zoster Ophthalmicus With Acquired Immunodeficiency Syndrome and Acute Retinal Necrosis

, 1993
We conducted a review to investigate the prevalence of human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS), in patients with herpes zoster ophthalmicus, as well as the incidence of acute retinal necrosis after herpes zoster ...
Schiffman, Joyce, Sellitti, Tony P, Davis, Janet L, Huang, Andrew J.W   +3 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Acute Retinal Necrosis Presenting With Optic Disc Edema

, 2019
Optic disc edema, a potential complication of acute retinal necrosis (ARN), usually develops concurrently or after the development of retinal abnormalities.
Yong-Il Shin; Ju-Mi Kim; Jung-Yeul Kim; Yeon-Hee Lee
core  

Hyaluronic Acid‐Based Photocurable Glue Application as an Alternative Surgical Approach for Corneal Injuries in Canine Patients: A Case Series

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
• Hyaluronic acid (HA)–based photocurable glue was applied to deep corneal injuries in dogs as a minimally invasive alternative when surgery was not feasible. • The adhesive was delivered to the lesion and rapidly photocrosslinked using 405 nm visible light, creating a stable protective barrier.
Myeongjee Kwon, Hyeseon Lee, Jungyeon Yong, Haerin Yoon, Jiyi Hwang, Ji Seung Jung, Donghee Kim, Sungin Lee, Seung Yun Yang, Kyung‐Mee Park   +9 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, Volume 16, Issue 6, Page 1150-1165, June 2026.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source