Results 1 to 10 of about 4,781,689 (344)

Acute and sub-acute toxicity study of a Pakistani polyherbal formulation

BMC Complementary and Alternative Medicine, 2017
Background Herbology is the prevailing system among the nationally-accepted alternative or complementary systems of medicine. The system is due to its general and patient-oriented methodology, is widely used in the general population exposing them to the
Saiqa Ishtiaq, Maida Akram, Sairah Hafeez Kamran, Uzma Hanif, Muhammad Shaharyar Khan Afridi, Sajid-ur-Rehman, Atika Afzal, Ayesha Asif, Muhammad Younus, Shehla Akbar   +9 more
doaj   +2 more sources

Evaluation of the in vivo and in vitro safety profile of Cuscuta epithymum ethanolic extract [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Cuscuta epithymum (CE) is one of the most popular medicinal plants in the world. However, detailed information about its toxicity is not available.
Mohammad Reza Abedini, Samaneh PAki, Mahtab Mohammadifard, Mohsen Foadoddini, Khadijeh Vazifeshenas-Darmiyan, Mehran Hosseini   +5 more
doaj   +1 more source

Proton Therapy of Prostate and Pelvic Lymph Nodes for High Risk Prostate Cancer: Acute Toxicity [PDF]

International Journal of Particle Therapy, 2021
Purpose: To assess acute gastrointestinal (GI) and genitourinary (GU) toxicities of intensity-modulated proton therapy (IMPT) targeting the prostate/seminal vesicles and pelvic lymph nodes for prostate cancer.
Richard Choo, MD, David W. Hillman, MS, Thomas Daniels, MD, Carlos Vargas, MD, Jean Claude Rwigema, MD, Kimberly Corbin, MD, Sameer Keole, MD, Sujay Vora, MD, Kenneth Merrell, MD, Bradley Stish, MD, Thomas Pisansky, MD, Brian Davis, MD, PhD, Adam Amundson, William Wong, MD   +13 more
doaj   +1 more source

Large-Scale Modeling of Multispecies Acute Toxicity End Points Using Consensus of Multitask Deep Learning Methods

Journal of Chemical Information and Modeling, 2021
Computational methods to predict molecular properties regarding safety and toxicology represent alternative approaches to expedite drug development, screen environmental chemicals, and thus significantly reduce associated time and costs.
Sankalp Jain, Vishal B. Siramshetty, Vinicius M. Alves, E. Muratov, N. Kleinstreuer, A. Tropsha, M. Nicklaus, A. Simeonov, A. Zakharov   +8 more
semanticscholar   +1 more source

CATMoS: Collaborative Acute Toxicity Modeling Suite

Environmental Health Perspectives, 2021
Background: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management ...
K. Mansouri, A. Karmaus, J. Fitzpatrick, G. Patlewicz, Prachi Pradeep, Domenico Alberga, N. Alépée, Timothy E. H. Allen, Dave Allen, Vinicius M. Alves, C. Andrade, T. Auernhammer, D. Ballabio, S. Bell, E. Benfenati, S. Bhattacharya, Joyce V Bastos, S. Boyd, J. B. Brown, Stephen J. Capuzzi, Y. Chushak, Heather L. Ciallella, A. Clark, V. Consonni, Pankaj R. Daga, S. Ekins, S. Farag, M. Fedorov, D. Fourches, Domenico Gadaleta, F. Gao, J. Gearhart, Garett Goh, J. Goodman, F. Grisoni, C. Grulke, T. Hartung, M. Hirn, Pavel Karpov, A. Korotcov, G. Lavado, Michael S. Lawless, Xinhao Li, T. Luechtefeld, F. Lunghini, G. Mangiatordi, G. Marcou, Dan Marsh, T. Martin, A. Mauri, E. Muratov, G. Myatt, Dac-Trung Nguyen, O. Nicolotti, R. Note, Paritosh Pande, Amanda K. Parks, Tyler Peryea, A. Polash, R. Rallo, A. Roncaglioni, C. Rowlands, P. Ruiz, Daniel P. Russo, Ahmed Sayed, Risa R. Sayre, Timothy K Sheils, Charles Siegel, Arthur C. Silva, A. Simeonov, S. Sosnin, Noel Southall, J. Strickland, Yun Tang, B. Teppen, I. Tetko, Dennis G. Thomas, Valery Tkachenko, R. Todeschini, Cosimo Toma, Ignacio Tripodi, D. Trisciuzzi, A. Tropsha, A. Varnek, K. Vukovic, Zhongyu Wang, Liguo Wang, K. Waters, Andrew J. Wedlake, Sanjeeva J. Wijeyesakere, Daniel M. Wilson, Zijun Xiao, Hongbin Yang, Gergely Zahoránszky-Kőhalmi, A. Zakharov, Fagen F Zhang, Zhen Zhang, Tongan Zhao, Hao Zhu, Kimberley M. Zorn, W. Casey, N. Kleinstreuer   +101 more
semanticscholar   +1 more source

Evaluation of the Acute and Sub-Acute Oral Toxicity of Jaranol in Kunming Mice

Frontiers in Pharmacology, 2022
Background: Jaranol has shown a wide range of pharmacological activities; however, no study has yet examined in vivo toxicity. The study aimed to investigate the oral acute and sub-acute toxicity of jaranol in mice.Methods: The acute toxicity was ...
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Xin Jia, Xin Jia, Yunfeng Xiao, Yunfeng Xiao, Lanbing Zheng, Yu Dong, Yu Dong   +11 more
doaj   +1 more source

Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

BMC Pharmacology and Toxicology, 2021
Background Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20–42 days).
Yan-Yu Zhang, Yu-Feng Huang, Jie Liang, Hua Zhou   +3 more
semanticscholar   +1 more source

Interspecies Quantitative Structure-Toxicity-Toxicity Relationships for Predicting the Acute Toxicity of Organophosphorous Compounds

Chemistry Proceedings, 2021
Median lethal concentration values are commonly used to express the relative risk related to the acute toxicity of chemicals. In this paper, we considered rat and mouse acute toxicity (LD50) data of organophosphorous compounds (OPs) with diverse ...
Gheorghe Ilia, Ana Borota, Simona Funar-Timofei   +2 more
doaj   +1 more source

PredAOT: a computational framework for prediction of acute oral toxicity based on multiple random forest models

BMC Bioinformatics, 2023
Background Acute oral toxicity of drug candidates can lead to drug development failure; thus, predicting the acute oral toxicity of small compounds is important for successful drug development.
Jae Yong Ryu, Woo Dae Jang, Jidon Jang, Kwang-Seok Oh   +3 more
doaj   +1 more source

Assessment of acute and sub-acute toxicity of olive pomace in female Wistar rats [PDF]

World Cancer Research Journal, 2022
Objective: Olive Pomace (OP) is considered to be a rich source of phenolic compounds. Recently many researches showed a broad biological activity of this by-product of the olive oil production process in addition to their emergence as value-added ...
Z. Badi, B. Guermouche, N. Haddam, N. Belyagoubi, K. Rouigueb, H. Benzerjeb, M. Dali-Sahi, Y. Kachekouche, H. Merzouk   +8 more
doaj   +1 more source