Results 31 to 40 of about 4,781,689 (344)

Evaluation of Acute and Repeated Dose Oral Toxicity of Phoenix dactylifera L. Pollen Methanolic Extract in Rats

Journal of Tropical Pharmacy and Chemistry
Pollen of the date palm (Phoenix dactylifera L.) has been used for thousands of years as a traditional herbal medicine for improving fertility. However, safety of plant-derived materials is an important concern to human health, and herbal remedies ...
Musab A. M. Abdelrahim, Elhadi M. M. Ahmed   +1 more
doaj   +1 more source

Size-dependent acute toxicity of silver nanoparticles in mice

Journal of Toxicologic Pathology, 2017
In this study, we aimed to evaluate changes in the acute toxicity of intraperitoneally administered silver nanoparticles (AgNPs) of varying sizes in BALB/c mice. Seven-week-old female BALB/c mice were intraperitoneally administered AgNPs measuring 10, 60,
Young-Man Cho, Y. Mizuta, Jun-ichi Akagi, T. Toyoda, Mizuki Sone, K. Ogawa   +5 more
semanticscholar   +1 more source

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity

Environmental Health Perspectives, 2020
Background: Modern chemical toxicology is facing a growing need to Reduce, Refine, and Replace animal tests (Russell 1959) for hazard identification.
Joyce V. B. Borba, Vinicius M. Alves, R. Braga, D. Korn, Kirsten Overdahl, Arthur C. Silva, Steven U S Hall, Erik Overdahl, J. Strickland, D. Allen, N. Kleinstreuer, C. Andrade, E. Muratov, A. Tropsha   +13 more
semanticscholar   +1 more source

Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer

Prostate Cancer, 2015
A small but meaningful percentage of men who are treated with external beam radiation therapy for prostate cancer will develop late gastrointestinal toxicity. While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials
Matthew Sean Peach, Timothy N. Showalter, Nitin Ohri   +2 more
doaj   +1 more source

Proton beam therapy delivered using pencil beam scanning vs. passive scattering/uniform scanning for localized prostate cancer: Comparative toxicity analysis of PCG 001-09

Clinical and Translational Radiation Oncology, 2019
Background and purpose: Patient-level benefits of proton beam therapy (PBT) relative to photon therapy for prostate cancer (PC) continue to be the focus of debate. Although trials comparing the two modalities are underway, most are being conducted using “
Mark V. Mishra, Rahul Khairnar, Søren M. Bentzen, Gary Larson, Henry Tsai, Christopher Sinesi, Carlos Vargas, George Laramore, Carl Rossi, Lane Rosen, Mingyao Zhu, William Hartsell   +11 more
doaj   +1 more source

Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii (Harms) J. Leonard stem barks (Caesalpiniaceae) in mice and rats

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii (Harms) J. Leonard (G. tessmannii) and evaluate its safety. Methods: NMRI mice were used to determine the acute toxicity of G. tessmannii. Increasing concentrations of the
Noreen Orianna Koumba Madingou, Aristide Traore, Alain Souza, Marlaine Michelle Boukandou Mounanga, Raissa Reine Aworet Samseny, Sylvin Ouedraogo, Alfred Sababenedyo Traore   +6 more
doaj   +1 more source

Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance

Interdisciplinary Toxicology, 2018
Safety assessment of chemicals, pharmaceuticals, food and food ingredients, cosmetics, industrial products is very crucial prior to their approval for human uses.
E. Erhirhie, C. Ihekwereme, E. Ilodigwe
semanticscholar   +1 more source

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 SETAC.An effort is ongoing to develop a biotic ligand model (BLM) that predicts copper (Cu) toxicity in estuarine and marine ...
de Polo, A, Scrimshaw, MD
core   +1 more source

Unraveling the safety of adjuvant radiotherapy in prostate cancer: impact of older age and hypofractionated regimens on acute and late toxicity - a multicenter comprehensive analysis

Frontiers in Oncology, 2023
BackgroundThe objective of this study was to assess the impact of age and other patient and treatment characteristics on toxicity in prostate cancer patients receiving adjuvant radiotherapy (RT).Materials and methodsThis observational study (ICAROS-1 ...
Milly Buwenge, Gabriella Macchia, Letizia Cavallini, Letizia Cavallini, Annalisa Cortesi, Claudio Malizia, Lorenzo Bianchi, Lorenzo Bianchi, Maria Ntreta, Alessandra Arcelli, Ilaria Capocaccia, Ilaria Capocaccia, Elena Natoli, Elena Natoli, Savino Cilla, Francesco Cellini, Francesco Cellini, Luca Tagliaferri, Lidia Strigari, Silvia Cammelli, Silvia Cammelli, Riccardo Schiavina, Riccardo Schiavina, Eugenio Brunocilla, Eugenio Brunocilla, Alessio Giuseppe Morganti, Alessio Giuseppe Morganti, Francesco Deodato, Francesco Deodato   +28 more
doaj   +1 more source

Acute Toxicity of Perfluorooctane Sulfonic Acid on Early Life Stages of Daphnia Magna, Siriella Armata, Paracentrotus Lividus Sea Urchin, and Turbot (Scophthalmus Maximus L.). [PDF]

, 2010
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant whose potential toxicity is causing great concern. In the present study, we used two crustaceans (_Daphnia magna_, _Siriella armata_), echinoid embryos (_Paracentrotus lividus_) and ...
Diego Real Conde, Lazhar Mhadhbi, Lazhar Mhadhbi, Moncef Boumaiza, Ricardo Beiras, Sara Pérez Fernandez   +5 more
core   +2 more sources