Results 51 to 60 of about 4,986,959 (302)

Acute Oral Toxicity

Biology Engineering Medicine and Science Reports, 2019
I am covering this simple and mundane acute toxicity test to increase the awareness, understanding and an appreciation of acute toxicity test, which has undergone sea-change in the last decade.
K. S. Rao
semanticscholar   +1 more source

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

Cell, 2021
Unprecedented advances have been made in cancer treatment with the use of immune checkpoint blockade (ICB). However, responses are limited to a subset of patients, and immune-related adverse events (irAEs) can be problematic, requiring treatment ...
Golnaz Morad, Beth A. Helmink, Padmanee Sharma, J. Wargo   +3 more
semanticscholar   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

An assessment of acute insecticide toxicity loading (AITL) of chemical pesticides used on agricultural land in the United States

PLoS ONE, 2019
We present a method for calculating the Acute Insecticide Toxicity Loading (AITL) on US agricultural lands and surrounding areas and an assessment of the changes in AITL from 1992 through 2014.
M. DiBartolomeis, S. Kegley, P. Mineau, Rosemarie Radford, Kendra Klein   +4 more
semanticscholar   +1 more source

ADMET evaluation in drug discovery: 15. Accurate prediction of rat oral acute toxicity using relevance vector machine and consensus modeling

Journal of Cheminformatics, 2016
Background Determination of acute toxicity, expressed as median lethal dose (LD50), is one of the most important steps in drug discovery pipeline. Because in vivo assays for oral acute toxicity in mammals are time-consuming and costly, there is thus an ...
Tailong Lei, Youyong Li, Yunlong Song, Dan Li, Huiyong Sun, Tingjun Hou   +5 more
semanticscholar   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Toxicological evaluation and preliminary phytochemical characterisation of a Nigerian Cannabis sativa chemovar [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Different Cannabis sativa chemovars produce diverse pharmacological and behavioral effects. With the widespread use of cannabis in Nigeria, detailed toxicological effects of Nigerian chemovars are lacking.
Ebele Ajagun, Babatunde Alabi, Abdul-musawwir Alli-oluwafuyi, Mary Ologe   +3 more
doaj   +1 more source

Acute human toxicity and mortality after selenium ingestion: A review.

Journal of Trace Elements in Medicine and Biology, 2019
BACKGROUND Although selenium is an essential element for humans, acute toxicity has been reported after high oral exposure. METHODS The published literature on the acute toxicity of oral selenium was gathered and reviewed.
N. Hadrup, G. Ravn-Haren
semanticscholar   +1 more source

Tracking Health Related Quality of Life From Diagnosis to Follow‐Up Among Australian Children With Acute Lymphoblastic Leukaemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows, Clarissa E. Schilstra, Karen McCleary, Nancy E. Briggs, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla‐Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Toby Trahair, Marion K. Mateos, Joanna E. Fardell   +19 more
wiley   +1 more source

Acute, sub-acute and developmental toxicity studies of molybdenum disulfide nanoflowers in rats, as per OECD guidelines

BMC Pharmacology and Toxicology
Background This study aimed to investigate the potential toxic effects of Molybdenum disulfide nano-flowers (MoS2 NF), which have been suggested as a chemotherapeutic agent, but lack previous toxicity studies.
Farina Hanif, Aslam Khan, Fareeha Anwar, Haseeb ullah, Muhammad Furqan Akhtar, Muhammad Imran Khan   +5 more
doaj   +1 more source