Results 121 to 130 of about 7,648 (236)
Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers
Medicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.ABSTRACT
In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang +6 morewiley +1 more sourcePatients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva
Orphanet Journal of Rare Diseases, 2020 Background Genetic contributors to cardiac arrhythmias are often found in cardiovascular conduction pathways and ion channel proteins. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disease of massive heterotopic ossification caused by a ...Samuel Kou, Carmen De Cunto, Geneviève Baujat, Kelly L. Wentworth, Donna R. Grogan, Matthew A. Brown, Maja Di Rocco, Richard Keen, Mona Al Mukaddam, Kim-Hanh le Quan Sang, Umesh Masharani, Frederick S. Kaplan, Robert J. Pignolo, Edward C. Hsiao +13 moredoaj +1 more sourceIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]
, 2017 We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.Adam Resnick, Alan Mackay, Alexei N. Kisljakov, Andrew J. Martin, Andrew S. Moore, André O. von Bueren, Angel Montero Carcaboso, Angela J. Waanders, Anna Burford, Baker, Barrow, Bax, Bender, Bjerke, Bouffet, Buczkowicz, Cai, Cai, Carmen de Torres, Carvalho, Castel, Ceccarelli, Chan, Chris Jones, Christopher Chandler, Cynthia Hawkins, Darach Crimmins, David Castel, David T.W. Jones, Davis, Diana Carvalho, Dmitry M. Konovalov, Dorra H’mida-Ben Brahim, Elisa Izquierdo, Fontebasso, Fontebasso, Funato, Grasso, Hamid Nikbakht, Harry J. Han, Hennika, Henry C. Mandeville, Ho-Keung Ng, Jacques Grill, Janat Fazal-Salom, Jane Cryan, Jane Pears, Jaume Mora, John Caird, Jones, Jones, Jones, João N. Stavale, Kathryn R. Taylor, Khuong-Quang, Korshunov, Korshunov, Kramm, Kun Mu, Leslie R. Bridges, Louis, Lucas T. Bidinotto, Ludmila I. Shats, Lynley Marshall, Lynn Bjerke, Mara Vinci, Marie-Anne Debily, Mariona Sunol, Maryam Fouladi, Matthew Clarke, Meera Nandhabalan, Michael Baudis, Michael Farrell, Michelle Monje, Nada Jabado, Natacha Entz-Werle, Nicolaides, Northcott, Ofelia Cruz, Ostrom, Paugh, Paugh, Paugh, Pichai Raman, Puget, Qin, Richards, Rui M. Reis, Safa Al-Sarraj, Saoussen Trabelsi, Sara Temelso, Saumya Gupta, Schiffman, Schwartzentruber, Sergey Popov, Shlien, Stefan M. Pfister, Stergios Zacharoulis, Sturm, Sturm, Sucheta Vaidya, Suzanne J. Baker, Taylor, Taylor, Temime-Smaali, Temime-Smaali, Tiberi, Valeria Molinari, Venkatesh, Welcker, Wu, Wu, Wu, Xingang Li, Yada, Yang, Zarghooni +116 morecore +8 more sourcesThe Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David MacEwan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes‐Peter Stasch, Scott A. Waldman +31 morewiley +1 more sourceThe therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]
, 2010 The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone +111 morecore +2 more sourcesBmpr2 Loss in the Vascular Endothelium Enhances Neoangiogenesis and Growth of Lung Metastatic Lesions in a Mouse Model of Breast Cancer
Journal of Cellular Biochemistry, Volume 126, Issue 11, November 2025.ABSTRACT
Bone morphogenetic protein‐9 (BMP9) has been implicated as a regulator of metastasis and tumor angiogenesis, with contrasting studies demonstrating both pro‐ and antiangiogenic roles for BMP9 across different cancer cell lines and animal models.Jordan A. Harry, Sofia I. Skebo, Devon V. Cole, Vincent Dinh, M. Martin VandenBroek, Abby K. Lee, Natasha Camacho, Hollie N. Piepjohn, Victoria Hoskin, Kimberly J. Laverty, Yan Gao, Douglas Quilty, Peter A. Greer, Mark L. Ormiston +13 morewiley +1 more sourceAnother Acvr1 Purification For Fragment Screening And Co-Crystallisation
, 2018 A rather unsuccessful purification, but nevertheless, enough for three crystal plates to follow up compound ...Adamson, Roslin, Matteucci, Mizio, Brennan, Paul, Bullock, Alex +3 moreopenaire +1 more sourceActivin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.
PLoS ONE, 2009 BackgroundActivin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon Barbara Jung, Jessica Gomez, Eddy Chau, Jennifer Cabral, Jeffrey K Lee, Aimee Anselm, Przemyslaw Slowik, Deena Ream-Robinson, Karen Messer, Judith Sporn, Sung K Shin, C Richard Boland, Ajay Goel, John M Carethers +13 moredoaj +1 more sourceCurrent state of therapeutic development for rare cancers in Japan, and proposals for improvement [PDF]
, 2018 This article discusses current obstacles to the rapid development of safe and effective treatments for rare cancers, and considers measures required to overcome these challenges.Ando Masashi, Goto Toshio, Heike Toshio, Kawai Akira, Kimura Shinya, Matsui Shigeyuki, Matsumoto Seiichi, Mizutani Shuki, Monden Morito, Nagata Kyosuke, Narukawa Mamoru, Nishikawa Akiyoshi, Shibata Taro, Shibata Tatsuhiro, Tani Kenzaburo, Toguchida Junya, Ueda Ryuzo, 永田 恭介 +17 morecore +2 more sourcesDecoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy
Medicinal Research Reviews, Volume 45, Issue 6, Page 1651-1661, November 2025.ABSTRACT
Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati +9 morewiley +1 more source
