Results 191 to 200 of about 6,796 (211)

ACVR1 is essential for periodontium development and promotes alveolar bone formation

Archives of Oral Biology, 2018
To explore the role of a BMP type I receptor (ACVR1) in regulating periodontium development, Acvr1 was conditionally disrupted in Osterix-expressing cells.Mandibles from both control (Acvr1 fx/+; Osterix-Cre (+)/(-)) and cKO (Acvr1 fx/-; Osterix-Cre (+)/(-)) mice at postnatal day 21 (PN21) were scanned by micro-CT, followed by decalcification and ...
Xue Zhang, Qilin Liu, Huan Zhao, Yue Hu, Cangwei Liu, Guangxing Yan, Daowei Li, Yuji Mishina, Ce Shi, Hongchen Sun   +9 more
openaire   +2 more sources

ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

Nature Genetics, 2014
Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.
Gelareh Zadeh, Kenneth Aldape
openaire   +1 more source

Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients

Clinical Genetics, 2010
Carvalho DR, Navarro MMM, Martins BJAF, Coelho KEFA, Mello WD, Takata RI, Speck‐Martins CE. Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients.Fibrodysplasia ossificans progressiva (FOP) is a severe genetic disorder reported worldwide.
D R, Carvalho, M M M, Navarro, B J A F, Martins, K E F A, Coelho, W D, Mello, R I, Takata, C E, Speck-Martins   +6 more
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ACVR1 gene mutations in four Turkish patients diagnosed as fibrodysplasia ossificans progressiva

Gene, 2013
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized with congenital malformations of the great toes and progressive heterotopic ossifications in the skeletal muscles and soft tissue. FOP has been associated with a specific point mutation on the ACVR1 (Activin A receptor type I) gene.
KIZILDAĞ, SEFA, Ozsoylu, Dua, Karatosun, VASFİ AKINCI, KAVUKÇU, SALİH, ERESEN YAZICIOĞLU, ÇİĞDEM   +4 more
openaire   +3 more sources

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation

Cellular Signalling
Tubulointerstitial fibrosis in the kidneys is a chronic and progressive process. Although studies suggested that tubular epithelial-mesenchymal transition (EMT) plays a key role in the development of kidney fibrosis, whether ACVR1, a member of the TGFβ superfamily, is involved in the EMT needs to be illustrated.
Tianli, Yu, Zhangyu, Mai, Shunhui, Zhang, Shunyi, Wang, Wenjin, Yang, Zhang, Ruan, Pinxian, Li, Fujia, Guo, Yining, Zhang, Jiangchao, Li, Lijing, Wang, Caixia, Lin, Lingyun, Zheng   +12 more
openaire   +2 more sources

Faculty Opinions recommendation of ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2022
openaire   +1 more source

ACVR1 Gene

2020
openaire   +1 more source

ACVR1 and Fibrodysplasia Ossificans Progressiva

2016
Frederick S. Kaplan, O. W. Towler, Eileen M. Shore   +2 more
openaire   +1 more source

ACVR1

2016
openaire   +1 more source

The Type I BMP Receptor ACVR1/ALK2 is Required for Chondrogenesis During Development

Journal of Bone and Mineral Research, 2015
Karen M Lyons, Teni Anbarchian
exaly