Results 211 to 220 of about 7,648 (236)

Monoallelic variants in ACVR1 in a cohort of Egyptian individuals with fibrodysplasia ossificans progressiva

Clinical Dysmorphology
Objectives Fibrodysplasia ossificans progressiva (FOP) is a rare ectopic ossification disorder of connective tissue deposited in the muscles, fascia, tendons, and ligaments.
R. Elhossini, H. El-Bassyouni, E. Ashaat, A. Ashour, Khaled Hamed, D. R. Soliman, Ibrahim M Hegazy, Sawsan Abdel-Hadi, H. Elbendary, M. Mehrez, N. Hassib, M. A. Al Kersh, Amal I. Othman, G. Abdel-Salam, Mohamed S. Abdel-Hamid, M. Aglan   +15 more
semanticscholar   +1 more source

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation.

Cellular Signalling
Tubulointerstitial fibrosis in the kidneys is a chronic and progressive process. Although studies suggested that tubular epithelial-mesenchymal transition (EMT) plays a key role in the development of kidney fibrosis, whether ACVR1, a member of the TGFβ superfamily, is involved in the EMT needs to be illustrated.
Tianli Yu, Zhangyu Mai, Shunhui Zhang, Shunyi Wang, Wenjin Yang, Zhang Ruan, Pinxian Li, Fujia Guo, Yining Zhang, Jiangchao Li, Lijing Wang, Caixia Lin, Lingyun Zheng   +12 more
semanticscholar   +3 more sources

Pro-tumor Macrophage Polarization Mediated by BMP2/4-ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment During Tumor Initiation.

Cancer Research
Cancer cells are able to evade immune surveillance by engendering an immunosuppressive "cold" tumor microenvironment (cTME). A better understanding of the mechanisms underlying the establishment of a cTME in the initial phases of tumor formation could ...
Mingchao Wang, Zhihong Song, Hao Yuan, Chang Liu, Wei Wang, Naixue Yang, Keyong Sun, Shanshan Zhang, Xianhan Qin, Jingwei Li, Chen Tian, Runda Xu, Yixin Huang, Shicheng Hu, Xin Nie, Zhixin Bie, Xinquan Liu, Yi Yao, Xin Lin, Chunhua Lin, Xun Lan   +20 more
semanticscholar   +1 more source

Abstract 204: Targeting tumor-stroma interactions: Prognostic and therapeutic implications of the ACVR1-BMP7 axis in colorectal cancer

Cancer Research
The tumor microenvironment plays a critical role in colorectal cancer (CRC) progression, with stromal signatures closely linked to poor prognoses and resistance to chemotherapy.
N. Miyoshi, Shinya Kato, S. Fujino, Soichiro Minami, Rie Mizumoto, Rie Hayashi, Kengo Haruma   +6 more
semanticscholar   +1 more source

Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.

Briefings in Functional Genomics, 2022
Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors.
Garima C. Nagar, Pooja Mittal, Shradheya R. R. Gupta, Monika Pahuja, Manisha Sanger, R. Mishra, Ashutosh Kumar Singh, I. Singh   +7 more
semanticscholar   +1 more source

ACVR1 is essential for periodontium development and promotes alveolar bone formation

Archives of Oral Biology, 2018
To explore the role of a BMP type I receptor (ACVR1) in regulating periodontium development, Acvr1 was conditionally disrupted in Osterix-expressing cells.Mandibles from both control (Acvr1 fx/+; Osterix-Cre (+)/(-)) and cKO (Acvr1 fx/-; Osterix-Cre (+)/(-)) mice at postnatal day 21 (PN21) were scanned by micro-CT, followed by decalcification and ...
Xue Zhang, Qilin Liu, Huan Zhao, Yue Hu, Cangwei Liu, Guangxing Yan, Daowei Li, Yuji Mishina, Ce Shi, Hongchen Sun   +9 more
openaire   +2 more sources

Bta-miR-301a targets ACVR1 to influence cleavage time and blastocyst formation rate of early embryos in cattle

Biology of Reproduction
Accumulating evidence indicates that paternally derived microRNAs play a crucial role in the development of early embryos and are regarded as the key factor in the successful development of somatic cell cloned embryos. In our previous study, bta-miR-301a
Heqiang Li, Jing Gao, Jingyi Wang, Baobao Zhao, Xiaonan Ma, Bihan Zhang, Changrong Lv, Hailian Qiao, Yongsheng Wang, S. Qing   +9 more
semanticscholar   +1 more source

Unlocking the Door for Precision Medicine in Rare Conditions: Structural and Functional Consequences of Missense ACVR1 Variants

Omics
Rare diseases and conditions have thus far received relatively less attention in the field of precision/personalized medicine than common chronic diseases.
Garima Nagar, Shradheya R R Gupta, Vanshika Rustagi, R. K. Pramod, Archana Singh, Monika Pahuja, I. Singh   +6 more
semanticscholar   +1 more source

ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

Nature Genetics, 2014
Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.
Gelareh Zadeh, Kenneth Aldape
openaire   +1 more source

Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients

Clinical Genetics, 2010
Carvalho DR, Navarro MMM, Martins BJAF, Coelho KEFA, Mello WD, Takata RI, Speck‐Martins CE. Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients.Fibrodysplasia ossificans progressiva (FOP) is a severe genetic disorder reported worldwide.
D R, Carvalho, M M M, Navarro, B J A F, Martins, K E F A, Coelho, W D, Mello, R I, Takata, C E, Speck-Martins   +6 more
openaire   +2 more sources