Results 191 to 200 of about 30,705 (216)
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Journal of Urology, 1983
Acyclovir, the new virucidal drug recently approved by the Food and Drug Administration for the treatment of herpes simplex virus (HSV), is the first available effective drug to treat such infections. Acyclovir boasts activity against four of the five major herpes-group viruses, including herpes simplex (types 1 and 2), varicella-zoster, and Epstein ...
T M, Appelboom, F P, Flowers
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Acyclovir, the new virucidal drug recently approved by the Food and Drug Administration for the treatment of herpes simplex virus (HSV), is the first available effective drug to treat such infections. Acyclovir boasts activity against four of the five major herpes-group viruses, including herpes simplex (types 1 and 2), varicella-zoster, and Epstein ...
T M, Appelboom, F P, Flowers
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Infection Control, 1986
In recent years there have been great advances made in antiviral therapy. One of the most promising of the new agents to be introduced is acyclovir. This antiviral, which selectively inhibits the replication of particular DNA viruses, is being used clinically in the treatment and prevention of viral infections caused by several of the herpes viruses ...
C A, Zabrosky, G, Milkovich
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In recent years there have been great advances made in antiviral therapy. One of the most promising of the new agents to be introduced is acyclovir. This antiviral, which selectively inhibits the replication of particular DNA viruses, is being used clinically in the treatment and prevention of viral infections caused by several of the herpes viruses ...
C A, Zabrosky, G, Milkovich
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Journal of Antimicrobial Chemotherapy, 1983
Acyclovir given intravenously in either low dose (5 mg/kg every 8 h) or high dose (500 mg/m2 every 8 h) significantly reduced pain and accelerated skin healing in acute herpes zoster occurring in otherwise healthy adults. The higher dose also significantly reduced the duration of viral shedding. No significant effect on post-herpetic neuralgia could be
Bonnie Bean +2 more
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Acyclovir given intravenously in either low dose (5 mg/kg every 8 h) or high dose (500 mg/m2 every 8 h) significantly reduced pain and accelerated skin healing in acute herpes zoster occurring in otherwise healthy adults. The higher dose also significantly reduced the duration of viral shedding. No significant effect on post-herpetic neuralgia could be
Bonnie Bean +2 more
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New England Journal of Medicine, 1992
REPORTS of the clinical efficacy of acyclovir, a selective and specific inhibitor of herpesvirus replication, appeared in the literature a decade ago.
Alastair J.J. Wood +2 more
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REPORTS of the clinical efficacy of acyclovir, a selective and specific inhibitor of herpesvirus replication, appeared in the literature a decade ago.
Alastair J.J. Wood +2 more
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Scandinavian Journal of Infectious Diseases, 1988
Acyclovir crystals in the urine of a 28-year-old woman are described. The patient received intravenous acyclovir for herpes encephalitis. The crystalluria was accompanied by impairment of the renal tubules as evidenced by increased urinary beta-2-microglobulin excretion. Consecutive series of 60 patients on oral acyclovir and 20 patients on intravenous
N A, Peterslund, M L, Larsen, H, Mygind
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Acyclovir crystals in the urine of a 28-year-old woman are described. The patient received intravenous acyclovir for herpes encephalitis. The crystalluria was accompanied by impairment of the renal tubules as evidenced by increased urinary beta-2-microglobulin excretion. Consecutive series of 60 patients on oral acyclovir and 20 patients on intravenous
N A, Peterslund, M L, Larsen, H, Mygind
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Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite
Translational Research, 2011For decades, acyclovir-induced nephrotoxicity was believed to be secondary to crystalluria. Clinical evidence of nephrotoxicity in the absence of crystalluria suggests that acyclovir induces direct insult to renal tubular cells. We postulated that acyclovir is metabolized by the alcohol dehydrogenase (ADH) enzyme to acyclovir aldehyde, which is ...
John R. Bend +4 more
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Expert Opinion on Drug Delivery, 2008
Herpes viruses (herpes simplex, varicella zoster, cytomegalovirus) are the main cause of a wide variety of human infections. Although the development of successful antiviral agents against infections caused by herpes viruses had been slow until the last decade, the production of delivery systems for acyclovir are a promising alternative.
CORTESI, Rita, ESPOSITO, Elisabetta
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Herpes viruses (herpes simplex, varicella zoster, cytomegalovirus) are the main cause of a wide variety of human infections. Although the development of successful antiviral agents against infections caused by herpes viruses had been slow until the last decade, the production of delivery systems for acyclovir are a promising alternative.
CORTESI, Rita, ESPOSITO, Elisabetta
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Pediatrics In Review, 2005
1. Elisabeth H. Villavicencio, MD, PhD 2. Gregg Talente, MD, MS 1. Brody School of Medicine at East Carolina University Greenville NC Antiviral Therapy for Varicella and Herpes Zoster. Arvin AM. Semin Pediatr Infect Dis. 2002;13 :12– 21[OpenUrl][1][CrossRef][2][PubMed][3] Oral Ganciclovir in Children: Pharmacokinetics, Safety, Tolerance ...
Gregg Talente +1 more
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1. Elisabeth H. Villavicencio, MD, PhD 2. Gregg Talente, MD, MS 1. Brody School of Medicine at East Carolina University Greenville NC Antiviral Therapy for Varicella and Herpes Zoster. Arvin AM. Semin Pediatr Infect Dis. 2002;13 :12– 21[OpenUrl][1][CrossRef][2][PubMed][3] Oral Ganciclovir in Children: Pharmacokinetics, Safety, Tolerance ...
Gregg Talente +1 more
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The American Journal of Medicine, 1982
Herpes simplex keratitis accounts for 50 percent of patients presenting at our corneal clinic. Studies of the use of acyclovir in dendritic and geographic ulceration and disciform keratitis are presented. In a double-blind study of acyclovir and idoxuridine in 60 patients with dendritic keratitis, acyclovir was shown to be superior and produced no ...
T. Ravenscroft +3 more
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Herpes simplex keratitis accounts for 50 percent of patients presenting at our corneal clinic. Studies of the use of acyclovir in dendritic and geographic ulceration and disciform keratitis are presented. In a double-blind study of acyclovir and idoxuridine in 60 patients with dendritic keratitis, acyclovir was shown to be superior and produced no ...
T. Ravenscroft +3 more
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