Natural Lactone-Based Quorum Sensing Inhibitors Attenuate Virulence in Pseudomonas aeruginosa. [PDF]
Chem BiodiversTargeting bacterial communication, lab‐generated lactones (Lx) inhibited biofilm formation and eliminated mature biofilms within 24–48 h. Lx treatment also suppressed pyocyanin and rhamnolipid production while downregulating rhlR expression, highlighting their promise as potent quorum‐sensing (QS) inhibitors and next‐generation antibiofilm therapeutics.
Chaturvedi S +5 more
europepmc +2 more sources
Acyl homoserine lactones from culture supernatants of Pseudomonas aeruginosa accelerate host immunomodulation. [PDF]
PLoS ONE, 2011 The virulence of Pseudomonas aeruginosa is multifactorial and under the control of quorum sensing signals, such as acyl homoserine lactones (AHLs). The importance of these molecules in the establishment of infection has been previously reported.
Ravi Kumar Gupta +2 more
doaj +1 more source
In Planta Biocontrol of Pectobacterium atrosepticum by Rhodococcus erythropolis Involves Silencing of Pathogen Communication by the Rhodococcal Gamma-Lactone Catabolic Pathway. [PDF]
PLoS ONE, 2013 The virulence of numerous Gram-negative bacteria is under the control of a quorum sensing process based on synthesis and perception of N-acyl homoserine lactones.
Corinne Barbey +10 more
doaj +1 more source
Improvement in calcified anaerobic granular sludge performance by exogenous acyl-homoserine lactones
Ecotoxicology and Environmental Safety, 2021 Given the high content of Ca2+ in waste paper recycling wastewater, the anaerobic granular sludge (AnGS) undergoes calcification during wastewater treatment and affects the treatment efficiency.
Meiling Li +7 more
doaj +1 more source
The Scientific World Journal, 2014 Many Proteobacteria communicate via production followed by response of quorum sensing molecules, namely, N-acyl homoserine lactones (AHLs). These molecules consist of a lactone moiety with N-acyl side chain with various chain lengths and degrees of ...
Kok-Gan Chan +4 more
doaj +1 more source
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
Marine Drugs, 2009 S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g ...
Janice R. Sufrin +2 more
doaj +1 more source
A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. [PDF]
PLoS ONE, 2011 In Pseudomonas aeruginosa, the expression of a number of virulence factors, as well as biofilm formation, are controlled by quorum sensing (QS). N-Acylhomoserine lactones (AHLs) are an important class of signaling molecules involved in bacterial QS and ...
Patrick Bijtenhoorn +13 more
doaj +1 more source
Pseudomonas fluorescens MFE01 uses 1-undecene as aerial communication molecule
Frontiers in Microbiology, 2023 Bacterial communication is a fundamental process used to synchronize gene expression and collective behavior among the bacterial population. The most studied bacterial communication system is quorum sensing, a cell density system, in which the ...
Charly A. Dupont +15 more
doaj +1 more source
Quorum Sensing Activity of Enterobacter asburiae Isolated from Lettuce Leaves
Sensors, 2013 Bacterial communication or quorum sensing (QS) is achieved via sensing of QS signaling molecules consisting of oligopeptides in Gram-positive bacteria and N-acyl homoserine lactones (AHL) in most Gram-negative bacteria.
Kok-Gan Chan +4 more
doaj +1 more source
Caffeine as a Potential Quorum Sensing Inhibitor
Sensors, 2013 Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown ...
Kok-Gan Chan +2 more
doaj +1 more source