Results 151 to 160 of about 47,958 (242)

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

Snapshots of acyl carrier protein shuttling in human fatty acid synthase. [PDF]

Nature
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R.   +7 more
europepmc   +1 more source

Identification of Novel Inhibitor of Enoyl-Acyl Carrier Protein Reductase (InhA) Enzyme in Mycobacterium tuberculosis from Plant-Derived Metabolites: An In Silico Study. [PDF]

Antibiotics (Basel), 2022
Singh K, Pandey N, Ahmad F, Upadhyay TK, Islam MH, Alshammari N, Saeed M, Al-Keridis LA, Sharma R.   +8 more
europepmc   +1 more source

Acyl carrier protein. IX. Acyl carrier protein hydrolase.

The Journal of biological chemistry, 1967
P R, Vagelos, A R, Larrabes
openaire   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, EarlyView.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Investigation of Potent Anti-<i>Mycobacterium tuberculosis</i> Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis. [PDF]

Drug Des Devel Ther
Sabt A, Korycka-Machala M, Kassem AF, The Son N, Ha NX, Brzostek A, Thabit MG, Kawka M, Dziadek B, Elshamy AI, Atwa AM, Dziadek J.   +11 more
europepmc   +1 more source

Atomistic insight on structure and dynamics of spinach acyl carrier protein with substrate length. [PDF]

Biophys J, 2021
Baer MD, Shanklin J, Raugei S.
europepmc   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Acyl carrier protein. X. Acyl carrier protein synthetase.

The Journal of biological chemistry, 1968
J, Elovson, P R, Vagelos
openaire   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source