Results 271 to 280 of about 80,359 (315)

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Expression and purification of four different rhizobial acyl carrier proteins The GenBank accession numbers for the nucleotide sequences reported in this paper are AF159244 and AF159243 for the acpP-containing regions of Sinorhizobium meliloti 1021 and of Rhizobium leguminosarum LPR5045, respectively.

, 2000
Isabel M. López‐Lara, Otto Geiger
openalex   +1 more source

Remolding Waste Liquid From the Zeolite Synthesis Process Into Wrinkled Dressings for Diabetic Wound Therapeutics With Immunomodulation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Waste liquid from natural clay‐to‐zeolite synthesis is remolded into a metal‐wrinkled dressing showing outstanding hemostatic, antibacterial, and wound‐healing effects. Chronic wounds resulting from diabetes are among the most common complications in diabetic patients.
Hanlin Yao, Xinyu You, Songqi Wu, Yunhao Wang, Di Hu, Yongsheng Ma, Jun Luo, Jie Qiu, Lihua Zhou   +8 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

An endogenous proteinacious inhibitor in porcine liver for S-adenosyl-l-methionine dependent methylation reactions: identification as oligosaccharide-linked acyl carrier protein

, 2000
Dong Wan Seo, Hyung In Moon, Jeung Whan Han, Sung Youl Hong, Hoi Young Lee, Sangduk Kim, Woon Ki Paik, Hyang Woo Lee   +7 more
openalex   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Identification and Substrate Specificity of β-Ketoacyl (Acyl Carrier Protein) Synthase III (mtFabH) from Mycobacterium tuberculosis

, 2000
Keum-Hwa Choi, Laurent Kremer, Gurdyal S. Besra, Charles O. Rock   +3 more
openalex   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

European Journal of Heart Failure, EarlyView.
LV, left ventricular; LVAD, left ventricular assist device; LVEF, left ventricular ejection fraction. Abstract Aims Perturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans.
Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt   +17 more
wiley   +1 more source

Structural Modeling and Site-Directed Mutagenesis of the Actinorhodin β-Ketoacyl-Acyl Carrier Protein Synthase

, 2000
Min He, Mustafa Varoglu, David H. Sherman   +2 more
openalex   +1 more source

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA)

Exploration, EarlyView.
Multidrug‐resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated
Jingqin Ye, Wenhua Huang, Shujuan Yu, Yan Guo, Peng Sun, Ziyuan Chen, Linhui Hao, Yan Zhang, Caixia Li, Yongqiang Jiang, Jun Wu, Li Zhu, Hengliang Wang, Chao Pan   +13 more
wiley   +1 more source