Results 291 to 300 of about 80,359 (315)

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

open access: yesiMeta, EarlyView.
By integrating multi‐level and multi‐omics analyses, we identify 3,4‐dihydroxyphenylacetic acid (DHPAA), a gut microbiota‐derived degradation product of dietary flavonoids, as a key bioactive end‐product responsible for the beneficial effects against polycystic ovary syndrome (PCOS).
Pan Li   +22 more
wiley   +1 more source

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

open access: yesiMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou   +19 more
wiley   +1 more source

Synthesis of Cellulose Hexanoate, Benzoate, and Mixed Esters: Exploring Their Potential as Enzyme Immobilization Platforms

open access: yesMacromolecular Bioscience, EarlyView.
Cellulose sourced from cotton linters was utilized to synthesize cellulose esters, specifically hexanoate, benzoate, and a mixed hexanoate‐benzoate variant, which were evaluated as platforms for enzyme immobilization. These esters were shaped into various architectural forms, including electrospun mats, layered sandwich structures, and spherical shapes.
Roberta Teixeira Polez   +5 more
wiley   +1 more source

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

open access: yesMacromolecular Rapid Communications, EarlyView.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu   +3 more
wiley   +1 more source
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Acylation of plant acyl carrier proteins by acyl-acyl carrier protein synthetase from Escherichia coli

Archives of Biochemistry and Biophysics, 1984
The acyl-acyl carrier protein synthetase from Escherichia coli has been examined for its ability to specifically acylate acyl carrier protein (ACP) from higher plants in order to develop an assay for plant ACP, and to prepare labeled acyl-ACP of plant origin. It was found that the E.
Tsung Min Kuo, John B. Ohlrogge
openaire   +3 more sources

Acyl carrier protein interacts with melittin

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
Acyl carrier protein (ACP) from Escherichia coli has been shown to form complexes with melittin, a cationic peptide from bee venom. ACP is a small (Mr 8847), acidic, Ca2(+)-binding protein, which possesses some characteristics resembling those of regulatory Ca2(+)-binding proteins including interaction with melittin. Complexing between melittin and ACP
Ernst-Fonberg, Mary L.   +2 more
openaire   +4 more sources

Improved purification of acyl carrier protein

Analytical Biochemistry, 1980
Abstract An improved method for the purification of acyl carrier protein from Escherichia coli is described. The method consists of four steps: a 2-propanol extraction, batch adsorption to DEAE-cellulose, ammonium sulfate fractionation, and acid precipitation.
John E. Cronan, Charles O. Rock
openaire   +3 more sources

Acyl carrier protein from E. coli. Structural characterization of short-chain acylated acyl carrier proteins by NMR

Biochemistry, 1985
Acylated acyl carrier proteins (ACPs) with acyl chain lengths of 2, 4, 6, 8, and 10 carbons were investigated by NMR and nuclear Overhauser methods at 500 MHz. Chemical shift changes of downfield aromatic and upfield, ring-current-shifted, isoleucine proton resonances monotonically vary as a function of acyl chain length with the most prominent shifts ...
Kevin H. Mayo, James H. Prestegard
openaire   +3 more sources

Desaturation of trans-octadecenoyl-acyl carrier protein by stearoyl-acyl carrier protein Δ9 desaturase

Journal of Inorganic Biochemistry, 2000
Positional isomers of mono-unsaturated 18:1-ACP have been used as substrates for stearoyl-acyl carrier protein delta9 desaturase to test whether a C-H bond abstraction from either the C-9 or C-10 position could lead to rearranged products diagnostic for the production of an allylic radical intermediate.
John A. Broadwater   +2 more
openaire   +3 more sources

Utilization of Enzymatically Phosphopantetheinylated Acyl Carrier Proteins and Acetyl−Acyl Carrier Proteins by the Actinorhodin Polyketide Synthase

Biochemistry, 1997
The functional reconstitution of two purified proteins of an aromatic polyketide synthase pathway, the acyl carrier protein (ACP) and holo-ACP synthase (ACPS), is described. Holo-ACPs were enzymatically synthesized from coenzyme A and apo-ACPs using Escherichia coli ACPS.
Christopher T. Walsh   +3 more
openaire   +3 more sources

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