Acyl-coenzyme A:cholesterol acyltransferases [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2009 The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist.
Bo-Liang Li +3 more
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Proofreading of Noncognate Acyl Adenylates by an Acyl-Coenzyme A Ligase
Chemistry & Biology, 2013 Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pretransfer editing by pimeloyl-coenzyme A (CoA) ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven-carbon dicarboxylic acid, to its CoA ester.
Miglena Manandhar, John E. Cronan
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Journal of Lipid Research, 1987 Acyl coenzyme A:cholesterol acyl transferase and/or cholesterol esterase may regulate the esterification and absorption of exogenous cholesterol. To assess this, mucosal acyl coenzyme A:cholesterol acyl transferase activity was inhibited selectively with
L L Gallo, J A Wadsworth, G V Vahouny
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Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization. [PDF]
J Neuroinflammation, 2023 Background We have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by targeting the cholesterol metabolizing enzyme acyl-coenzyme A: cholesterol transferase 1 (ACAT1 ...
Zaidi SAH +8 more
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ON THE MECHANISM OF DEHYDROGENATION OF FATTY ACYL DERIVATIVES OF COENZYME A
Journal of Biological Chemistry, 1956 Helmut Beinert +4 more
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Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury. [PDF]
J Pharmacol Exp Ther, 2022 Acute lung injury (ALI) is characterized by epithelial damage, barrier dysfunction, and pulmonary edema. Macrophage activation and failure to resolve play a role in ALI; thus, macrophage phenotype modulation is a rational target for therapeutic ...
Stevenson ER +4 more
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FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. [PDF]
J Cell Biol, 2020 FIT2 is a protein important for ER lipid metabolism and lipid droplet formation, but its function has remained mysterious. Becuwe et al. show that FIT2 is an acyl coenzyme A diphosphatase, and this activity is crucial for ER homeostasis and cellular ...
Becuwe M +12 more
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Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI). [PDF]
Cell Death Dis, 2020 Acyl coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI) is a multifunctional protein with an intracellular action (as ACBP), as well as with an extracellular role (as DBI). The plasma levels of soluble ACBP/DBI are elevated
Joseph A +36 more
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Acyl‐coenzyme A organizes laterally in membranes and is recognized specifically by acyl‐coenzyme A binding protein [PDF]
FEBS Letters, 2003 Long chain acyl‐coenzyme A (acyl‐CoA) is a biochemically important amphiphilic molecule that is known to partition strongly into membranes by insertion of the acyl chain. At present, microscopically resolved evidence is lacking on how acyl‐CoA influences and organizes laterally in membranes. By atomic force microscopy (AFM) imaging of membranes exposed
Cohen Simonsen, A. +4 more
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Acyl Coenzyme A Synthetase Regulation: Putative Role in Long‐Chain Acyl Coenzyme A Partitioning [PDF]
Obesity Research, 2004 AbstractObjective: Long‐chain acyl coenzyme A synthetase (ACSL) converts free fatty acids (FFAs) into their metabolizable long‐chain acyl coenzyme A (LC‐CoA) derivatives that are essential for FFA conversion to CO2, triglycerides, or complex lipids. ACSL‐1 is highly expressed in adipose tissue with broad substrate specificity.
Yan-Lin Wang +8 more
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