Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment [PDF]
Anticancer Research, 2019 Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment.
Judyta, Zabielska +2 more
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Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint". [PDF]
Aging Cell, 2023 Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI), is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic radiation.
Montégut L +7 more
europepmc +2 more sources
Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization. [PDF]
J Neuroinflammation, 2023 Background We have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by targeting the cholesterol metabolizing enzyme acyl-coenzyme A: cholesterol transferase 1 (ACAT1 ...
Zaidi SAH +8 more
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Proofreading of Noncognate Acyl Adenylates by an Acyl-Coenzyme A Ligase
Chemistry & Biology, 2013 Aminoacyl-tRNA synthetases remove (proofread) incorrect substrates and thereby prevent errors in protein synthesis. We report enzyme-catalyzed pretransfer editing by pimeloyl-coenzyme A (CoA) ligase (BioW), a biotin synthetic enzyme that converts pimelate, a seven-carbon dicarboxylic acid, to its CoA ester.
Manandhar, Miglena, Cronan, John E.
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Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function [PDF]
Scientific Reports, 2018 Medium-chain acyl-Coenzyme A dehydrogenase (MCAD) is involved in the initial step of mitochondrial fatty acid β-oxidation (FAO). Loss of function results in MCAD deficiency, a disorder that usually presents in childhood with hypoketotic hypoglycemia ...
Sze Chern Lim +7 more
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Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury. [PDF]
J Pharmacol Exp Ther, 2022 Acute lung injury (ALI) is characterized by epithelial damage, barrier dysfunction, and pulmonary edema. Macrophage activation and failure to resolve play a role in ALI; thus, macrophage phenotype modulation is a rational target for therapeutic ...
Stevenson ER +4 more
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FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. [PDF]
J Cell Biol, 2020 FIT2 is a protein important for ER lipid metabolism and lipid droplet formation, but its function has remained mysterious. Becuwe et al. show that FIT2 is an acyl coenzyme A diphosphatase, and this activity is crucial for ER homeostasis and cellular ...
Becuwe M +12 more
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mBio, 2022 We provide the first evidence for the role of ACSL4 in enterovirus replication organelle formation. Moreover, both enteroviruses and coronaviruses induce ferroptosis via ACSL4.
Yu-An Kung +11 more
semanticscholar +1 more source
Transcriptional Regulation by the Short-Chain Fatty Acyl Coenzyme A Regulator (ScfR) PccR Controls Propionyl Coenzyme A Assimilation by Rhodobacter sphaeroides [PDF]
Journal of Bacteriology, 2015 Michael S. Carter, Birgit E. Alber
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