Results 71 to 80 of about 2,608,587 (304)

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, EarlyView.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

Anisotropic relaxation in NADH excited states studied by polarization-modulation pump-probe transient spectroscopy [PDF]

, 2020
We present the results of experimental and theoretical studies of fast anisotropic relaxation and rotational diffusion in the first electron excited state of biological coenzyme NADH in water-ethanol solutions. The experiments have been carried out by means of a novel polarization-modulation transient method and fluorescence polarization spectroscopy ...
arxiv   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Induction of Cell Death by Combined Treatment with Photosensitizer‐Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study demonstrates that combination of phosphosensitizer‐conjugated chitosan nanoparticles and ferroptosis inducer RSL3 increases cell death in mesenchymal breast cancer cells. Data suggests that this is attributed to variations in ferroptosis‐related protein expression, lipid peroxydation and mitochondrial function.
Marek Feith, Saikat Das Sajib, Anne Grethe Myrann, Anders Høgset, Pablo Garrido, Alfredo Martinez, Erik Knutsen, Kirsten Sandvig, Tore Skotland, Gunhild Mari Mælandsmo, Tore‐Geir Iversen   +10 more
wiley   +1 more source

Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7

Journal of Lipid Research, 2007
Lipid droplets (LDs) function as intracellular storage depots of neutral lipids. Recently, we identified long-chain acyl-coenzyme A synthetase 3 (ACSL3) as a major LD-associated protein in the human hepatocyte cell line HuH7.
Yasuyuki Fujimoto, Hiroyuki Itabe, Tetsuaki Kinoshita, Koichi J. Homma, Jun Onoduka, Masahiro Mori, Shinji Yamaguchi, Minoru Makita, Yusuke Higashi, Atsushi Yamashita, Tatsuya Takano   +10 more
doaj  

The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases

Life, 2023
Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product.
Yu Meng, Cheryl Ingram-Smith, Oly Ahmed, Kerry Smith   +3 more
doaj   +1 more source

Acyl Coenzyme A Binding Protein [PDF]

Journal of Biological Chemistry, 1998
Cellular unbound long chain fatty acyl-CoAs (>14 carbon) are potent regulators of gene transcription and intracellular signaling. Although the cytosolic acyl-CoA binding protein (ACBP) has high affinity for medium chain fatty acyl-CoAs, direct interaction of ACBP with >14-carbon fatty acyl-CoAs has not been established.
Andrey Frolov, Friedhelm Schroeder
openaire   +3 more sources

Clinical and genetical heterogeneity of late-onset multiple acyl-coenzyme A dehydrogenase deficiency

Orphanet Journal of Rare Diseases, 2014
BackgroundMultiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive disorder caused by deficiency of electron transfer flavoprotein or electron transfer flavoprotein dehydrogenase.
S. Grünert
semanticscholar   +1 more source

Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases.

Journal of Infectious Diseases, 2014
BACKGROUND Cryptosporidium is emerging as 1 of the 4 leading diarrheal pathogens in children in developing countries. Its infections in patients with AIDS can be fatal, whereas fully effective treatments are unavailable.
Fengguang Guo, Haili Zhang, Jason Fritzler, S. D. Rider, Lixin Xiang, Nina Mcnair, J. Mead, G. Zhu   +7 more
semanticscholar   +1 more source

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters.

Rapid Communications in Mass Spectrometry, 2014
RATIONALE Acyl-Coenzyme A (CoA) thioesters are the principal form of activated carboxylates in cells and tissues. They are employed as acyl carriers that facilitate the transfer of acyl groups to lipids and proteins.
N. Snyder, Sankha S. Basu, Zinan Zhou, A. Worth, I. Blair   +4 more
semanticscholar   +1 more source