Results 71 to 80 of about 31,319 (243)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

5‐thiohistidine N‐acetyltransferase from Proteiniphilum saccharofermentans

ChemBioChem, Accepted Article.
Ovothiol A is a 5‐thiohistidine derivative biosynthesized by a broad range of prokaryotic and eukaryotic organisms. Its redox‐active mercaptoimidazole side chain is believed to protect cells from oxidative stress. The three enzymes that produce ovothiol A from histidine, cysteine, and S‐adenosyl methionine have been identified and characterized.
Cangsong Liao, David Lim, Gladwin Suryatin Alim, Florian P. Seebeck   +3 more
wiley   +1 more source

Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)‐N’‐Benzylidenepyrazine‐2‐Carbohydrazides and their Derivatives

ChemMedChem, EarlyView.
(E)‐N’‐benzylidenepyrazine‐2‐carbohydrazides with 2‐OH, 2,3‐diOH or 2,4‐diOH substitution exhibit good antimycobacterial or antiproliferative activity, and iron chelation similar to salicylaldehyde isonicotinoyl hydrazone (SIH). A series of 33 (E)‐N’‐benzylidenepyrazine‐2‐carbohydrazides and their derivatives were synthesized and tested for biological ...
Priam‐Amedeo Houngbedji, Daria Elżbieta Nawrot, Ondřej Janďourek, Klára Konečná, Martin Novák, Pavla Paterová, Pavel Bárta, Martina Hrast Rambaher, Eva Novotná, Carlo Castellano, Matteo Mori, Fiorella Meneghetti, Monika Záhorszká, Jana Korduláková, Jan Zitko   +14 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

European Journal of Heart Failure, EarlyView.
LV, left ventricular; LVAD, left ventricular assist device; LVEF, left ventricular ejection fraction. Abstract Aims Perturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans.
Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt   +17 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Revisiting Cholesterol‐Lowering Nutraceuticals and Functional Foods: Mechanistic Insights Into Cholesterol Homeostasis and Gut Microbiota

Food Chemistry International, EarlyView.
Mechanistic Insights into Cholesterol Homeostasis and Gut Microbiota. ABSTRACT The gut microbiota acts as a crucial intermediary between diets and human health. The accumulating evidence suggests that gut microbiota may play a significant role in cholesterol metabolism.
Xiaoxuan Zhang, Huafang Ding, Wensen He, Shouhe Huang, Lin Lei   +4 more
wiley   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

Food Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo, Evelyne Nkirote Gikundi, Mercy Adhiambo Ndiege, Kevin Omondi Aduol   +3 more
wiley   +1 more source

A microfluorometric method for the determination of free fatty acids in plasma

Journal of Lipid Research, 1983
A rapid and precise microfluorometric method for the determination of free fatty acid concentrations in 2-5 microliters of plasma is described. The assay is performed directly on plasma, eliminating the need for extraction with organic solvents, and is ...
J Miles, R Glasscock, J Aikens, J Gerich, M Haymond   +4 more
doaj   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, EarlyView.
Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons during rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic lipids and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production of ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source