Results 51 to 60 of about 12,040 (158)
This review surveys the literature on light‐driven dearomative [2+2] cycloadditions of indoles, highlighting their power to access complex cyclobuta[b]indole frameworks. Advances in photocatalysis, sensitizer design, and reaction engineering enable selective and sustainable assembly of strained three‐dimensional architectures, expanding opportunities ...
Maria Chiara Cabua +4 more
wiley +1 more source
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan +7 more
wiley +1 more source
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei +5 more
wiley +1 more source
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand +8 more
wiley +1 more source
Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini +3 more
wiley +1 more source
Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley +1 more source
Simvastatin synergizes with cisplatin in cisplatin‐resistant cervical cancer cells through suppression of the caveolin‐1‐mediated PI3K/AKT signaling axis. ABSTRACT Cervical cancer treatment is often hindered by the emergence of cisplatin (DDP) resistance. Increasing evidence has indicated that statins possess anti‐tumor and chemosensitization potential
Yujia Zhou +7 more
wiley +1 more source
(150) Syntheses of Acyl Fluorides
Hisao Kitano, Ken-ichi Fukui
openaire +2 more sources
AgBF<sub>4</sub>-catalyzed insertion of unactivated alkynes into C-F bonds of acyl fluorides. [PDF]
Emmei T, Tobisu M.
europepmc +1 more source
Synthesis of <i>N</i>-Substituted Hydroxamic Acids through a Pentafluoropyridine-Mediated Procedure. [PDF]
Bonn DE +3 more
europepmc +1 more source

