Results 51 to 60 of about 73,496 (185)

Fluoride and public health

, 2008
Irish Expert Body on Fluorides and Health / [200?
Irish Expert Body on Fluorides and Health
core  

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes

, 2015
The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl ...
Melanie S. Sanford (1246980), Sydonie D. Schimler (1262673), Douglas C. Bland (1262679), Sarah J. Ryan (1617253)   +3 more
core   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Acyl Fluorides as Efficient Electrophiles for the Copper-Catalyzed Boroacylation of Allenes

, 2017
The copper-catalyzed reaction of allenes with bis(pinacolato)diboron and acyl electrophiles is reported. In this transformation, acyl fluorides have been proven to be more efficient coupling partners than their chloride or carboxylate analogues.
Gagosz, Fabien, Boreux, Arnaud, Kiran Indukuri, Gagosz, F., Fabien Gagosz, Olivier Riant, Riant, Olivier, Indukuri, Kiran, Arnaud Boreux   +8 more
core   +1 more source

Enabling Cross‐Coupling Reactivity of α‐Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc α‐SF5 Reagent

Chemistry – A European Journal, EarlyView.
This work describes the first example of a thermally stable α‐SF5 organometallic reagent, which allows for extensive downstream functionalization by allylation and acylation reactions under copper catalysis, as well as palladium‐catalyzed Negishi‐type cross‐coupling conditions up to 96% yield. In silico analysis shines initial light on the requirements
Lujie Xu, David Rombach
wiley   +1 more source

Electrochemical Fluorination of Partially Fluorinated Dialkylethers. Synthesis of Sevoflurane Derivatives (CF3)2CHOCHF2, (CF3)2CHOCF3, and (CF3)2CFOCF3

Chemistry – A European Journal, EarlyView.
Electrochemical fluorination (ECF, Simons process) is a valuable method for the fluorination of partially fluorinated dialkyl ethers, providing an inexpensive, scalable, and safe access to partially fluorinated ethers with a higher fluorine content and the perfluorinated analogues that are hardly accessible using other fluorination techniques ...
Tanja Knuplez, Leon N. Schneider, Erik R. Csapo, Peer Kirsch, Nikolai V. Ignat'ev, Maik Finze   +5 more
wiley   +1 more source

Synthesis of Chiral‐at‐Sulfur(VI) Sulfonimidamide Brønsted Acids

Chemistry – A European Journal, EarlyView.
A simple, modular route to chiral‐at‐sulfur(VI) Brønsted acids is described, delivering S‐chiral sulfonimidamides, C2‐symmetric acids, and BINOL‐based hybrid systems through stereospecific reactions of sulfonimidoyl fluorides and chlorides. ABSTRACT Herein, we report an efficient and simple strategy to access diverse chiral‐at‐sulfur(VI) Brønsted acids.
Yu Han, Natassa Lional, Dieuwertje E. Streefkerk, Jesse M. S. Goed, Bo Chen, Han Zuilhof, Fedor M. Miloserdov   +6 more
wiley   +1 more source