Actions of Pharmaceutical Lactones and Lactams on the Enzymes with Lactonase Activity: In Silico Prediction and In Vitro Study. [PDF]
Int J Mol SciEfremenko E +3 more
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Correction: <i>N</i>-acyl-homoserine lactone-based quorum sensing beyond canonical lineages: insights from Actinomycetota. [PDF]
Front MicrobiolFrontiers Production Office.
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Homocysteine thiolactone from translation proofreading is an endogenous ligand for cell-cell signaling by the receptor SdiA. [PDF]
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Listening in on Bacteria: Acyl-Homoserine Lactone Signalling
Nature Reviews Molecular Cell Biology, 2002Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other systems have been discovered only recently.
Clay Fuqua, Everett Peter Greenberg
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A Novel Plasmid for Detection of N-Acyl Homoserine Lactones [PDF]
Plasmid, 2009 Many bacteria utilize acyl-homoserine lactones as cell to cell signals that can regulate the expression of numerous genes. Structural differences in acyl-homoserine lactones produced by different bacteria, such as acyl side chain length and the presence or absence of an oxy group, make many of the commonly used detection bioassays impractical for broad
Everett C. Pesci
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Bacillus megaterium CYP102A1 Oxidation of Acyl Homoserine Lactones and Acyl Homoserines
Biochemistry, 2007Quorum sensing, the ability of bacteria to sense their own population density through the synthesis and detection of small molecule signals, has received a great deal of attention in recent years. Acyl homoserine lactones (AHLs) are a major class of quorum sensing signaling molecules. In nature, some bacteria that do not synthesize AHLs themselves have
Puneet K, Chowdhary +5 more
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Thiourea-catalyzed aminolysis of N-acyl homoserine lactones
Chemical Communications, 2013Thiourea catalysts accelerate aminolysis of N-acyl homoserine lactones (AHLs), molecules integral to bacterial quorum sensing. The catalysts afford rate enhancement of up to 10 times the control in CD(3)CN. Mild catalysis in other polar aprotic solvents is still observed, while the activity is attenuated in polar protic solvents.
Michael A, Bertucci +2 more
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Solution structural features of N -acyl homoserine lactones
Tetrahedron Letters, 2015Here we demonstrate that in interbacterial quorum signal moderators, N-acylhomoserine lactones (AHLs), the stabilization of bioactive pharmacophore lactone against lysis is through the e(-) withdrawing N-acyl motif which reduces lactone carbonyl polarization. This lysis is assisted by weak (
Tumminakatti, Shama +4 more
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Modeling the effect of acylated homoserine lactone antagonists in Pseudomonas aeruginosa
Biosystems, 2005Pseudomonas aeruginosa is a gram-negative bacterium that causes serious illnesses, particularly in immunocompromised individuals, often with a fatal outcome. The finding that the acylated homoserine lactone quorum sensing (QS) system controls the production of virulence factors in P.
Magnus G, Fagerlind +5 more
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Self perception in bacteria: quorum sensing with acylated homoserine lactones
Current Opinion in Microbiology, 1998A variety of Gram-negative bacteria produce membrane permeant, acylated homoserine lactone (HL) pheromones that act as cell density cues. Synthesis and response to these factors requires proteins homologous to the Luxl acylhomoserine lactone synthase and the LuxR transcription factor from Vibrio fischeri.
C, Fuqua, E P, Greenberg
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