Results 41 to 50 of about 9,779 (207)

Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control

Journal of Biological Chemistry, 2020
Enzymes able to degrade or modify acyl-homoserine lactones (AHLs) have drawn considerable interest for their ability to interfere with the bacterial communication process referred to as quorum sensing. Many proteobacteria use AHL to coordinate virulence and biofilm formation in a cell density-dependent manner; thus, AHL-interfering enzymes constitute ...
Billot, Raphael, Plener, Laure, Jacquet, Pauline, Elias, Mikael, Chabriere, Eric, Daude, David   +5 more
openaire   +2 more sources

Acyl-ACP Substrate Recognition inBurkholderia malleiBmaI1 Acyl-Homoserine Lactone Synthase [PDF]

Biochemistry, 2014
The acyl-homoserine lactone (AHL) autoinducer mediated quorum sensing regulates virulence in several pathogenic bacteria. The hallmark of an efficient quorum sensing system relies on the tight specificity in the signal generated by each bacterium. Since AHL signal specificity is derived from the acyl-chain of the acyl-ACP (ACP = acyl carrier protein ...
Montebello, Aubrey N., Brecht, Ryan M., Turner, Remington D., Ghali, Miranda, Pu, Xinzhu, Nagarajan, Rajesh   +5 more
openaire   +3 more sources

Tandem Mass Spectrometry Detection of Quorum Sensing Activity in Multidrug Resistant Clinical Isolate Acinetobacter baumannii

The Scientific World Journal, 2014
Many Proteobacteria communicate via production followed by response of quorum sensing molecules, namely, N-acyl homoserine lactones (AHLs). These molecules consist of a lactone moiety with N-acyl side chain with various chain lengths and degrees of ...
Kok-Gan Chan, Huey Jia Cheng, Jian Woon Chen, Wai-Fong Yin, Yun Fong Ngeow   +4 more
doaj   +1 more source

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Marine Drugs, 2009
S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g ...
Janice R. Sufrin, Steven Finckbeiner, Colin M. Oliver   +2 more
doaj   +1 more source

Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo [PDF]

, 2017
The expression of certain bacterial genes is regulated in a cell-density dependent way, a phenomenon called quorum sensing. Both Gram-negative and Gram-positive bacteria use this type of communication, though the signal molecules (auto-inducers) used by ...
Andersen, Asano, Bala, Baldrich, Balkwill, Bandyopadhaya, Barber, Barr, Barrett, Bart De Spiegeleer, Bassler, Baxter, Belleza, Beloin, Bultman, Campagna, Castro-Nallar, Cataldi, Cataldi, Charlesworth, Charlton, Chen, Chen, Chhabra, Chowers, Christophe Van de Wiele, Clarke, Cooley, Cryan, Darkoh, De Spiegeleer, De Spiegeleer, DiMango, Dolnick, Dunny, Eloe-Fadrosh, Engebrecht, Erdman, Erickson, Ernst, Evelien Wynendaele, Fekete, Finegold, Flavier, Frederick Verbeke, Freestone, Frommberger, Frommberger, Frommberger, Fuqua, Gomi, Gregus, Gupta, Haas, Higgins, Holden, Holzer, Hooi, Hughes, Håvarstein, Ike, Jahoor, Jiang, Junio, Kalia, Karavolos, Karavolos, Karavolos, Kaufmann, Kendall, Kolodkin-Gal, Kravchenko, Kravchenko, Kubesová, Kumar, Kumari, La Rosa, Li, Li, Li, Li, Lyte, Lyte, Lyte, Lyte, Malik, Marchesan, Mayer, McNab, Mello, Miyairi, Moos, Mori, Mori, Mori, Mori, Mori, Morin, Murray, Nakayama, Nakayama, Nakayama, Naseribafrouei, Nathan Debunne, Nealson, Nealson, Nilsen, O'Connor, O'Mahony, Oleskin, Oliver, Ortori, Pacheco, Parekh, Patel, Pearman, Pereira, Pesci, Pesci, Petersen, Pozzi, Pritchard, Pritchard, Procaccini, Rai, Rasko, Raut, Rickard, Rickard, Rutherford, Ryan, Severine De Craemer, Shaw, Sifri, Singh, Skindersoe, Smith, Smith, Smith, Spencer, Sperandio, Steindler, Stilling, Struss, Sturme, Suzuki, Syvitski, Taga, Tateda, Telford, Telford, Teplitski, Thaiss, Thiel, Thomas, Tian, Todd, Tomova, van der Meer, Vikström, Wagner, Wang, Wei, Wynendaele, Wynendaele, Wynendaele, Yamashita, Yorick Janssens, Zackular, Zhang, Zhou, Zhou, Zimmermann   +172 more
core   +2 more sources

Rapid Acyl-Homoserine Lactone Quorum Signal Biodegradation in Diverse Soils [PDF]

Applied and Environmental Microbiology, 2005
ABSTRACT Signal degradation impacts all communications. Although acyl-homoserine lactone (acyl-HSL) quorum-sensing signals are known to be degraded by defined laboratory cultures, little is known about their stability in nature. Here, we show that acyl-HSLs are biodegraded in soils sampled from diverse U.S.
Wang, Ya-Juan, Leadbetter, Jared Renton
openaire   +5 more sources

A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. [PDF]

PLoS ONE, 2011
In Pseudomonas aeruginosa, the expression of a number of virulence factors, as well as biofilm formation, are controlled by quorum sensing (QS). N-Acylhomoserine lactones (AHLs) are an important class of signaling molecules involved in bacterial QS and ...
Patrick Bijtenhoorn, Hubert Mayerhofer, Jochen Müller-Dieckmann, Christian Utpatel, Christina Schipper, Claudia Hornung, Matthias Szesny, Stephanie Grond, Andrea Thürmer, Elzbieta Brzuszkiewicz, Rolf Daniel, Katja Dierking, Hinrich Schulenburg, Wolfgang R Streit   +13 more
doaj   +1 more source

Pseudomonas fluorescens MFE01 uses 1-undecene as aerial communication molecule

Frontiers in Microbiology, 2023
Bacterial communication is a fundamental process used to synchronize gene expression and collective behavior among the bacterial population. The most studied bacterial communication system is quorum sensing, a cell density system, in which the ...
Charly A. Dupont, Charly A. Dupont, Yvann Bourigault, Yvann Bourigault, Théo Osmond, Théo Osmond, Maëva Nier, Corinne Barbey, Corinne Barbey, Xavier Latour, Xavier Latour, Yoan Konto-Ghiorghi, Yoan Konto-Ghiorghi, Julien Verdon, Annabelle Merieau, Annabelle Merieau   +15 more
doaj   +1 more source

Evaluation of a new high-throughput method for identifying quorum quenching bacteria [PDF]

, 2013
Quorum sensing (QS) is a population-dependent mechanism for bacteria to synchronize social behaviors such as secretion of virulence factors. The enzymatic interruption of QS, termed quorum quenching (QQ), has been suggested as a promising alternative ...
Bossier, Peter, Coenye, Tom, Shi, Xiaochong, Tang, Kaihao, Yu, Min, Zhang, Xiao-Hua, Zhang, Yunhui   +6 more
core   +2 more sources

Enzymatic Assays to Investigate Acyl-Homoserine Lactone Autoinducer Synthases [PDF]

, 2017
Bacteria use chemical molecules called autoinducers as votes to poll their numerical strength in a colony. This polling mechanism, commonly referred to as quorum sensing, enables bacteria to build a social network and provide a collective response for fighting off common threats.
Daniel, Shin, Rajesh, Nagarajan
openaire   +2 more sources