Results 1 to 10 of about 20,316 (189)

Paediatric CSF acylcarnitine reference ranges [PDF]

Frontiers in Molecular Biosciences
Acylcarnitines play a crucial role in energy metabolism pathways, primarily known for their involvement in the beta oxidation of fatty acids. However, their roles extend beyond mitochondrial transport; they also contribute to the synthesis of lipids in ...
Ontefetse Neo Plaatjie, A. Marceline Tutu Van Furth, A. Marceline Tutu Van Furth, Regan Solomons, Martijn Van Der Kuip, Shayne Mason   +5 more
doaj   +2 more sources

Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model

Metabolites, 2022
Hypoxic-ischemic brain injury (HIBI) leads to depletion of ATP, mitochondrial dysfunction, and enhanced oxidant formation. Measurement of acylcarnitines may provide insight into mitochondrial dysfunction.
Amanda M. Dave, Thiago C. Genaro-Mattos, Zeljka Korade, Eric S. Peeples   +3 more
doaj   +1 more source

Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

eLife, 2023
Endocytosis through Drosophila glia is a significant determinant of sleep amount and occurs preferentially during sleep in glia of the blood-brain barrier (BBB).
Fu Li, Gregory Artiushin, Amita Sehgal
doaj   +1 more source

The association and prediction value of acylcarnitine on diabetic nephropathy in Chinese patients with type 2 diabetes mellitus

Diabetology & Metabolic Syndrome, 2023
Background Acylcarnitines play a role in type 2 diabetes mellitus (T2DM), but the relationship between acylcarnitine and diabetic nephropathy was unclear.
Xuerui Li, Yuyang Miao, Zhongze Fang, Qiang Zhang   +3 more
doaj   +1 more source

Management of pregnancy in a patient with long‐chain 3‐hydroxyacyl CoA dehydrogenase deficiency

JIMD Reports, 2022
Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is a rare mitochondrial defect of β‐oxidation of long‐chain fatty acids. Patients may present with muscle pain, hypotonia, peripheral neuropathy, cardiomyopathy, recurrent rhabdomyolysis and ...
Loai A. Shakerdi, Jenny McNulty, Barbara Gillman, Claire M. McCarthy, Jessica Ivory, Alison Sheerin, James J. O'Byrne, Jennifer C. Donnelly, Eileen P. Treacy   +8 more
doaj   +1 more source

Dataset from dried blood spot acylcarnitine for detection of Carnitine-Acylcarnitine Translocase (CACT) deficiency and Carnitine Palmitoyl Transferase 2 (CPT2) deficiency

Data in Brief, 2023
Clinical diagnosis of inborn errors of metabolism in the suspected patients is usually guided by the initial general investigations in the laboratory such as the concentration of ammonia, blood gases status, blood glucose and ketones.
Anasufiza Habib, Muhammad Irfan Bukhari Ahmad Nazri, Salina Abdul Rahman   +2 more
doaj   +1 more source

Comparison of serum acylcarnitine levels in patients with myalgic encephalomyelitis/chronic fatigue syndrome and healthy controls: a systematic review and meta-analysis

Journal of Translational Medicine, 2023
Background Myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease (ME/CFS/SEID) is a condition diagnosed primarily based on clinical symptoms, including prolonged fatigue and post-exertional malaise; however, there is no
Ryuhei Jinushi, Sakue Masuda, Yuki Tanisaka, Sho Nishiguchi, Kento Shionoya, Ryo Sato, Kei Sugimoto, Takahiro Shin, Rie Shiomi, Akashi Fujita, Masafumi Mizuide, Shomei Ryozawa   +11 more
doaj   +1 more source

High-throughput quantitation of amino acids and acylcarnitine in cerebrospinal fluid: identification of PCNSL biomarkers and potential metabolic messengers

Frontiers in Molecular Biosciences, 2023
Background: Due to the poor prognosis and rising occurrence, there is a crucial need to improve the diagnosis of Primary Central Nervous System Lymphoma (PCNSL), which is a rare type of non-Hodgkin’s lymphoma. This study utilized targeted metabolomics of
Jingjing Ma, Kun Chen, Yun Ding, Xiao Li, Qiming Tang, Bo Jin, Ruben Y. Luo, Sheeno Thyparambil, Zhi Han, C. James Chou, Ashlee Zhou, James Schilling, Zhiguang Lin, Yan Ma, Qing Li, Mengxue Zhang, Karl G. Sylvester, Seema Nagpal, Doff B. McElhinney, Xuefeng B. Ling, Bobin Chen   +20 more
doaj   +1 more source

Metabolomics profile and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe intermediate metabolites associated with the development of atherosclerotic cardiovascular disease (ASCVD) remain largely unknown. Thus, we conducted a large panel of metabolomics profiling to identify the new candidate metabolites that ...
Hojat Dehghanbanadaki, Salimeh Dodangeh, Peyvand Parhizkar Roudsari, Shaghayegh Hosseinkhani, Pouria Khashayar, Mohammad Noorchenarboo, Negar Rezaei, Arezou Dilmaghani-Marand, Moein Yoosefi, Babak Arjmand, Kazem Khalagi, Kazem Khalagi, Niloufar Najjar, Ardeshir Kakaei, Fatemeh Bandarian, Hamid Aghaei Meybodi, Bagher Larijani, Farideh Razi   +17 more
doaj   +1 more source

Metabolomic Phenotype of Hepatic Steatosis and Fibrosis in Mexican Children Living with Obesity

Medicina, 2023
Background and Objectives: Metabolic-dysfunction-associated steatotic liver disease or MASLD is the main cause of chronic liver diseases in children, and it is estimated to affect 35% of children living with obesity.
Nayely Garibay-Nieto, Karen Pedraza-Escudero, Isabel Omaña-Guzmán, María José Garcés-Hernández, Eréndira Villanueva-Ortega, Mariana Flores-Torres, José Luis Pérez-Hernández, Mireya León-Hernández, Estibalitz Laresgoiti-Servitje, Berenice Palacios-González, Juan Carlos López-Alvarenga, Mauricio Lisker-Melman, Felipe Vadillo-Ortega   +12 more
doaj   +1 more source