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Gut microbiota-derived metabolite isovalerylcarnitine modulates salt sensitivity of blood pressure and incident hypertension: a multicenter dietary salt intervention trial. [PDF]

Nat Commun
Lin Z, Li S, Liu M, Li J, Liu F, Cao J, Chen S, Huang K, Wang Y, Li H, Wang Y, Yang B, Xing D, Wang Q, Ji X, Bai X, Hu D, Zhang M, Guo D, Huang J, Geng B, Gu D, Lu X.   +22 more
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Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
Acylcarnitines have been linked to obesity-induced insulin resistance. However the majority of these studies have focused on acylcarnitines in plasma. It is currently unclear to what extent plasma levels of acylcarnitines reflect tissue acylcarnitine metabolism.
Schooneman, Marieke G., Achterkamp, Niki, Argmann, Carmen A., Soeters, Maarten R., Houten, Sander M.   +4 more
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Acylcarnitines in intermediary metabolism

European Journal of Pediatrics, 1995
From the time of its discovery in 1905 until the first description of its deficiency in 1973, the role of carnitine in intermediary metabolism was decidedly vague. Identification of carnitine acyl transferases and their products, acylcarnitines, have paved the way to the confirmation of the importance of carnitine in the transfer of fatty acid CoAs ...
A C, Sewell, H J, Böhles
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Recommendations for acylcarnitine profile analysis

Annales de Biologie Clinique, 2020
Biochemical diagnosis of hereditary metabolic diseases requires the detection and simultaneous identification of a large number of compounds, hence the interest in metabolic profiles. Acylcarnitine profile allows the identification and quantification of more than thirty compounds.
Marie, Nowoczyn, Cécile, Acquaviva-Bourdain, Christelle, Corne, Régine, Minet-Quinard, Laetitia, Van Noolen, Roselyne, Garnotel, Anne-Frédérique, Dessein   +6 more
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Synthesis of dicarboxylic acylcarnitines

Chemistry and Physics of Lipids, 2004
Syntheses of malonyl, methylmalonyl, succinyl, glutaryl, methylglutaryl, dodecanedioyl and hexadecanedioyl carnitines are described. The dicarboxylic acylcarnitines were prepared from eight equivalents of cyclic anhydride or isopropylidene ester of the dicarboxylic acid and carnitine chloride in trifluoroacetic acid solution.
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Carnitine-Acylcarnitine Translocase Deficiency

The American Journal of the Medical Sciences, 1999
Carnitine-acylcarnitine translocase deficiency, like other defects of mitochondrial fatty acid oxidation, is an autosomal, recessively inherited disorder. When the deficiency is near total, it is usually fatal, affects life soon after birth, and constitutes one of the causes of skeletal muscle myopathy, cardiac and liver abnormalities, and childhood ...
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Acylcarnitine profile in thyroid disease

Clinical Biochemistry, 2013
To examine acylcarnitine profiles in individuals with hypo- or hyperthyroidism, and determine whether any atypical acylcarnitine species identified would normalize with correction of thyroid status.Serum acylcarnitine levels were measured in hypo- and hyperthyroid subjects before and after treatment with thyroxine or thionamide therapy respectively.No ...
Sophia, Wong, Fady, Hannah-Shmouni, Graham, Sinclair, Sandra, Sirrs, Marshall, Dahl, Andre, Mattman   +5 more
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Human Forearm Arteriovenous Differences of Carnitine, Short-Chain Acylcarnitine and Long-Chain Acylcarnitine

Clinical Science, 1989
1. Forearm arterial and venous concentrations of free carnitine, short-chain acylcarnitine, long-chain acylcarnitine, glucose, lactate, pyruvate, alanine, non-esterified fatty acids, glycerol, 3-hydroxybutyrate and acetoacetate were measured in fasted adult subjects. 2. In all subjects there was net uptake of short-chain acylcarnitine, 3-
K, Bartlett, A K, Bhuiyan, A, Aynsley-Green, P C, Butler, K G, Alberti   +4 more
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