Results 31 to 40 of about 20,316 (189)

Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D

Metabolites, 2022
Pharmacological interventions are essential for the treatment and management of critical illness. Although women comprise a large proportion of the critically ill, sex-specific pharmacological properties are poorly described in critical care.
Sowmya Chary, Karin Amrein, Sherif H. Mahmoud, Jessica A. Lasky-Su, Kenneth B. Christopher   +4 more
doaj   +1 more source

Quantitative acylcarnitine determination by UHPLC-MS/MS — Going beyond tandem MS acylcarnitine “profiles” [PDF]

Molecular Genetics and Metabolism, 2015
Tandem MS "profiling" of acylcarnitines and amino acids was conceived as a first-tier screening method, and its application to expanded newborn screening has been enormously successful. However, unlike amino acid screening (which uses amino acid analysis as its second-tier validation of screening results), acylcarnitine "profiling" also assumed the ...
Paul E, Minkler, Maria S K, Stoll, Stephen T, Ingalls, Janos, Kerner, Charles L, Hoppel   +4 more
openaire   +2 more sources

Relationship Between Acylcarnitine and the Risk of Retinopathy in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2022
ObjectiveDiabetic retinopathy is a common complication of type 2 diabetes mellitus (T2DM). Due to the limited effectiveness of current prevention and treatment methods, new biomarkers are urgently needed for the prevention and diagnosis of DR. This study
Wan-Ying Wang, Xu Liu, Xiao-Qian Gao, Xin Li, Zhong-Ze Fang   +4 more
doaj   +1 more source

Plasma Levels of Propionylcarnitine Improved Prediction of Heart Failure and All-Cause Mortality in Patients with Stable Coronary Artery Disease

Biomolecules
Background: Plasma metabolites could be suitable as predictive biomarkers for cardiovascular pathologies or death, thereby improving the prediction of protein biomarkers. The release of acylcarnitines may be altered after coronary artery disease (CAD) in
Jairo Lumpuy-Castillo, Francisco J. Rupérez, Brenda Lee Simas Porto, Carmen Cristóbal, Nieves Tarín, Ana Isabel Huelmos, Joaquín Alonso, Jesús Egido, Ignacio Mahíllo-Fernández, Lorenzo López-Bescós, José Tuñón, Óscar Lorenzo   +11 more
doaj   +1 more source

Amino Acid and Acylcarnitine Levels in Chronic Patients with Schizophrenia: A Preliminary Study

Metabolites, 2021
Amino acids and acylcarnitines play an important role as substrates and intermediate products in most of pathways involved in schizophrenia development such as mitochondrial dysfunction, inflammation, lipid oxidation, DNA damage, oxidative stress, and ...
Irina A. Mednova, Alexander A. Chernonosov, Marat F. Kasakin, Elena G. Kornetova, Arkadiy V. Semke, Nikolay A. Bokhan, Vladimir V. Koval, Svetlana A. Ivanova   +7 more
doaj   +1 more source

Profiling of Carnitine Shuttle System Intermediates in Gliomas Using Solid-Phase Microextraction (SPME)

Molecules, 2021
Alterations in the carnitine shuttle system may be an indication of the presence of cancer. As such, in-depth analyses of this pathway in different malignant tumors could be important for the detection and treatment of this disease.
Joanna Bogusiewicz, Katarzyna Burlikowska, Karol Jaroch, Paulina Zofia Gorynska, Krzysztof Gorynski, Marcin Birski, Jacek Furtak, Dariusz Paczkowski, Marek Harat, Barbara Bojko   +9 more
doaj   +1 more source

Interpretable machine learning identifies metabolites associated with glomerular filtration rate in type 2 diabetes patients

Frontiers in Endocrinology
ObjectiveThe co-occurrence of kidney disease in patients with type 2 diabetes (T2D) is a major public health challenge. Although early detection and intervention can prevent or slow down the progression, the commonly used estimated glomerular filtration ...
Tian-Feng An, Zhi-Peng Zhang, Jun-Tang Xue, Wei-Ming Luo, Yang Li, Zhong-Ze Fang, Zhong-Ze Fang, Guo-Wei Zong   +7 more
doaj   +1 more source

Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity

Journal of Lipid Research, 2012
During cocaine-induced hepatotoxicity, lipid accumulation occurs prior to necrotic cell death in the liver. However, the exact influences of cocaine on the homeostasis of lipid metabolism remain largely unknown. In this study, the progression of subacute
Xiaolei Shi, Dan Yao, Blake A. Gosnell, Chi Chen   +3 more
doaj   +1 more source

Arginine, as a Key Indicator for Real-Time Stability Monitoring of Quality Control in the Newborn Screening Test Using Dried Blood Spot

Separations, 2021
Dried blood spots (DBS) have advantages such as minimizing blood collection volume and the distress to neonate. DBS have been used for tandem mass spectrometry (MS/MS)-based newborn screening tests (NST) of amino acid (AA) and acylcarnitine.
Hyun-Seung Lee
doaj   +1 more source

L-Carnitine Effects on Clinical Status and Mortality Rate in Septic Patients: A Systematic Literature Review [PDF]

Journal of Fasting and Health, 2020
Introduction: Sepsis is one of the major causes of high morbidity and mortality in intensive care units (ICU) and severe sepsis leads to some metabolic disorder.
Farveh Yahyapoor, Naseh Pahlavani, karim karbin, Alireza Sedaghat, Majid Khadem-rezaiyan, Mostafa Arabi, Sudiyeh Hejri Zarifi, Abdolreza Norouzy   +7 more
doaj   +1 more source