Results 61 to 70 of about 20,316 (189)
Molecular Genetics and Metabolism ReportsBackground: Immediately after birth, adaptation to the extrauterine environment includes an upregulation of fatty acid catabolism. Cystic fibrosis and untreated hypothyroidism exert a life-long impact on fatty acid metabolism, but their influence during ...
Catherina T. Pinnaro +3 more
doaj +1 more source
Lipids, EarlyView.ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun +11 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Emerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl‐coenzyme A desaturase (SCD), impacts on α‐synuclein pathology in the Parkinson's disease (PD) brain. Objective The objective of this study was to analyze SCD and MUFA‐enriched lipids in the periphery of patients ...
Finula I. Isik +5 more
wiley +1 more source
Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management
Rheumatology &Autoimmunity, EarlyView.Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley +1 more source
Journal of Lipid Research, 1976 The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235–543, 1972) and modified by Bøhmer et al (Clin. Chim. Acta. 57:55–61, 1974) has been improved and simplified. As a result, the assay yields a linear
J D McGarry, D W Foster
doaj +1 more source
The Swedish National Pediatric Cataract Register (PECARE): Coexisting systemic disorders 2007–2023
Acta Ophthalmologica, EarlyView.Abstract Purpose To analyse the frequency and type of coexisting systemic disorders in children operated on for cataract in Sweden. Methods Data were retrieved from the Swedish National Pediatric Cataract Register (PECARE) for children operated between January 1, 2007, and December 31, 2023 (n = 975), including follow‐ups at age 1, 2, 5 and 10 ...
David Wackerberg +9 more
wiley +1 more source
Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?
Diabetes, Metabolic Syndrome and Obesity, 2022 Xiaodie Mu,1,* Min Yang,1,* Peiyao Ling,1,* Aihua Wu,1 Hua Zhou,1 Jingting Jiang2 1Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Tumor Biological ...
Mu X +5 more
doaj
Antenatal and Neonatal Management of Siblings With Carbonic Anhydrase VA Deficiency. [PDF]
JIMD RepABSTRACT Carbonic anhydrase VA (CAVA) deficiency (OMIM 114761) is an ultra‐rare inborn error of metabolism with fewer than 20 cases described. Affected infants present in the first days of life with hyperammonaemia, lactic acidosis, ketonaemia and encephalopathy.
Manoy S +10 more
europepmc +2 more sources
Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells
Brain Pathology, EarlyView.Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son +7 more
wiley +1 more source