Results 121 to 130 of about 1,339 (180)

Exploring the Conformational Effects of <i>N</i>- and <i>C</i>-Methylation of <i>N</i>-Acylhydrazones. [PDF]

ACS Omega
Franco LS, Alves MA, Sant'Anna CMR, de Sena Bastos IT, Barroso RCR, Costa FN, Ferreira FF, Fraga CAM, Barreiro EJ, Lima LM, Rodrigues DA, Pinheiro PSM.   +11 more
europepmc   +1 more source

Selective sensing of cyanide ions: impact of molecular design and assembly on the response of π-conjugated acylhydrazone compounds. [PDF]

RSC Adv
Barkale HV, Dey N.
europepmc   +1 more source

Iron-Based Nanoparticles as Delivery Tools. [PDF]

Pharmaceuticals (Basel)
Parang K, Vadlapatla R, Koomer A, Moran V, Jackson L, Shirazi AN.   +5 more
europepmc   +1 more source

Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog. [PDF]

Pharmaceuticals (Basel)
Guerra FS, Freitas RHCN, Moldovan F, Rocha DRD, Carvalho RS, Fernandes PD.   +5 more
europepmc   +1 more source

Injectable, self-healing and degradable dynamic hydrogels with tunable mechanical properties and stability by thermal-induced micellization. [PDF]

RSC Adv
Lin C, Chen L, He Y, Xiang W, Nie Y, Cai B, Guo Z.   +6 more
europepmc   +1 more source

A new <i>N</i>-acylhydrazone oxadiazole derivative with activity against mycobacteria. [PDF]

Future Microbiol
Souza IV, Fróes da Motta Dacome ML, Frederico Rozada AM, Rosa JS, Sampiron EG, Ferreira DG, Gauze GF, Norman Negri MF, de Lima Scodro RB, Cardoso RF, Caleffi-Ferracioli KR.   +10 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Acylhydrazone derivatives: a patent review

Expert Opinion on Therapeutic Patents, 2014
The N-acylhydrazone (NAH) moiety has been characterized as a privileged structure, capable of providing ligands points for more than one type of bioreceptor. Modifications of the subunits bonded to its acyl and imine functions resulted in several derivatives, which modulate a great diversity of molecular targets.
Rodolfo do Couto, Maia, Roberta, Tesch, Carlos Alberto Manssour, Fraga   +2 more
openaire   +4 more sources

Discovery of novel acylhydrazone neuraminidase inhibitors

European Journal of Medicinal Chemistry, 2019
Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza virus. NA inhibitors have been developed as effective treatments for influenza A and B infections. In this paper, a new lead neuraminidase inhibitor 6a (IC50 = 7.10 ± 0.2 μM) was discovered by ligand-based virtual screening, receptor-based virtual screening ...
Zhi Xiang Zhao, Li Ping Cheng, Meng Li, Wan Pang, Fan Hong Wu   +4 more
openaire   +4 more sources

N-Acylhydrazones as drugs

Bioorganic & Medicinal Chemistry Letters, 2018
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs
Sreekanth, Thota, Daniel A, Rodrigues, Pedro de Sena Murteira, Pinheiro, Lídia M, Lima, Carlos A M, Fraga, Eliezer J, Barreiro   +5 more
openaire   +2 more sources

N-Acylhydrazones as inhibitors of PDE10A

Bioorganic & Medicinal Chemistry Letters, 2011
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
Jennifer L, Gage, Rene, Onrust, Derek, Johnston, Andrew, Osnowski, Wendy, Macdonald, Lee, Mitchell, László, Urögdi, Alex, Rohde, Kevin, Harbol, Sasha, Gragerov, György, Dormán, Tom, Wheeler, Vince, Florio, Neil S, Cutshall   +13 more
openaire   +2 more sources