British Journal of Pharmacology, EarlyView.Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth +14 more
wiley +1 more source
Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Cell Proliferation, EarlyView.Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
What Is the Functional Role of the Acyltransferase-like Domain in the Svx Peptidase of the Phytopathogenic Bacterium <i>Pectobacterium atrosepticum</i>? [PDF]
Int J Mol SciTendiuk N +5 more
europepmc +1 more source
Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism
The FEBS Journal, EarlyView.Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley +1 more source
LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation. [PDF]
J Lipid ResXu Y +5 more
europepmc +1 more source
Dual IRE1 targets: Determinants of the cell fate?
The FEBS Journal, EarlyView.IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat +3 more
wiley +1 more source
Ten-year clinical course of familial lecithin-cholesterol acyltransferase deficiency caused by Cys74Tyr mutation leading to dialysis and multiple systemic complications: a case report. [PDF]
CEN Case RepYamazaki T +7 more
europepmc +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
Genome-Wide Identification and Analysis of BAHD Acyltransferases Involved in Anthocyanin Biosynthesis in <i>Perilla frutescens</i>. [PDF]
Biology (Basel)Zhou P, Gao B, Fei C, Luo J, Gong L.
europepmc +1 more source