Results 271 to 280 of about 48,697 (308)
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[7] Coenzyme a-independent acyltransferase
1992Publisher Summary This chapter describes coenzyme A-independent acyltransferase. The coenzyme A (CoA)-independent transacylation system catalyzes the transfer of fatty acids from diradyl phospholipids to various lysophospholipids in the absence of any cofactors, differing from the CoA-dependent transacylation reaction, which requires the presence of ...
Takayuki Sugiura, Keizo Waku
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[10] Dihydroxyacetone phosphate acyltransferase
1992Publisher Summary Dihydroxyacetone phosphate acyltransferase (DHAPAT) catalyzes the transfer of the fatty acid moiety from long-chain acyl-coenzyme A (acyl-CoA) to the free hydroxyl group of dihydroxyacetone phosphate. This reaction initiates the synthesis of the ether-linked glycerolipids and the more common glycerol ester lipids.
Keith O. Webber, Amiya K. Hajra
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Serine carboxypeptidase-like acyltransferases
Phytochemistry, 2004In plant secondary metabolism, an alternative pathway of ester formation is facilitated by acyltransferases accepting 1-O-beta-acetal esters (1-O-beta-glucose esters) as acyl donors instead of coenzyme A thioesters. Molecular data indicate homology of these transferases with hydrolases of the serine carboxypeptidase type defining them as serine ...
Dieter Strack, Carsten Milkowski
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[11] Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine
1992Publisher Summary The acylation of diacylglycerol catalyzed by the diacylglycerol acyltransferase is the only enzyme reaction unique to triacylglycerol synthesis. This reaction lies at the diacylglycerol branch point of phosphatidylcholine, phosphatidylethanolamine, and triacylglycerol synthesis.
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Mechanism and function of DHHC S-acyltransferases
Biochemical Society Transactions, 2013Protein S-palmitoylation is a reversible post-translational modification of proteins with fatty acids. In the last 5 years, improved proteomic methods have increased the number of proteins identified as substrates for palmitoylation from tens to hundreds.
Benjamin C. Jennings, Maurine E. Linder
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1983
Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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Publisher Summary This chapter focuses on carnitine acyltransferases. The carnitine enzyme with a large acyl transfer capacity for acetyl residues is called “carnitine acetyltransferase” (CAT), whereas the enzyme, which has a high transfer capacity for palmityl residues, is named “carnitine palmityltransferase” (CPT).
Loran L. Bieber, Shawn Farrell
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Inhibition of acyltransferase in lymphocytes by concanavalin A
Biochimica et Biophysica Acta (BBA) - General Subjects, 1980The effects of concanavalin A and succinylated concanavalin A on the transformation of mouse splenic lymphocytes, and on early biochemical events in the transformation, were compared. 1. The transformation of lymphocytes is biphasic with respect to concanavalin A concentration with optimal activation at about 1 microgram/ml.
Alan Mellors, Paul Dobson
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Acyltransferases and Triacylglycerols
2018Glycerolipids, by far the largest group of plant lipids, are structurally based on glycerol. This group includes glycodiacylglycerols, phospholipids, and acylglycerols such as triacylglycerol. The properties of the triacylglycerols depend on the fatty acids esterified with each of the three hydroxyl groups of glycerol.
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DHHC2 is a proteinS-acyltransferase for Lck
Molecular Membrane Biology, 2011Lck is a non-receptor tyrosine kinase of the Src family that is essential for T cell activation. Dual N-terminal acylation of Lck with myristate (N-acylation) and palmitate (S-acylation) is essential for its membrane association and function. Reversible S-acylation of Lck is observed in vivo and may function as a control mechanism. Here we identify the
Zeidman, Ruth +5 more
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Inhibitors of Acyl CoA:Cholesterol Acyltransferase
Journal of Medicinal Chemistry, 1996Conformational restriction of previously disclosed acyclic (diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4-Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 microM in an in vitro rat hepatic microsomal ...
Rosy Sher +9 more
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