Results 271 to 280 of about 63,314 (347)

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT The invention of a therapeutic begins by characterizing features that differentiate healthy versus diseased states; this often presents as changes in the concentration of an analyte. Examples include elevated blood glucose in diabetes, high cholesterol in heart disease, and protein aggregation in neurodegeneration.
Rebecca A. Kohnz   +10 more
wiley   +1 more source

Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts. [PDF]

open access: yesFront Plant Sci
Tiozon RN   +7 more
europepmc   +1 more source

Genetic and transcriptomic analysis of lentil seed imbibition and dormancy in relation to its domestication

open access: yesThe Plant Genome, Volume 18, Issue 2, June 2025.
Abstract Seed dormancy is an adaptation that delays germination to prevent the start of this process during unsuitable conditions. It is crucial in wild species but its loss was selected during crop domestication to ensure a fast and uniform germination. Water uptake, or imbibition, is the first step of germination.
Azalea Guerra‐García   +5 more
wiley   +1 more source

A maize landrace introgression library reveals a negative effect of root‐to‐shoot ratio on water‐use efficiency

open access: yesThe Plant Genome, Volume 18, Issue 2, June 2025.
Abstract Novel sources of genetic variability for water‐use efficiency (WUE) are needed in order to breed varieties more suitable to sustainable cropping systems. Here, a maize (Zea mays L.) introgression library of the landrace Gaspé Flint into the reference line B73 was characterized in high‐throughput phenotyping platforms, both in well‐watered and ...
Giuseppe Sciara   +9 more
wiley   +1 more source

Influence of Produced Water and Light Irradiation on the Composition of Exopolysaccharide Produced by L. amnigena Evaluated by Raman Spectroscopy

open access: yesBiopolymers, Volume 116, Issue 3, May 2025.
Changes in the composition of the EPS produced by L. amnigena in different culture media and irradiated by Laser or LED light sources and studied using Raman spectroscopy showed peaks of fucose, glucose, galactose, glucuronic acid and mannose. PCA showed the presence of acyl groups (mainly pyruvyl) depending on the production conditions and irradiation.
Anna Paula Lima Teixeira da Silva   +7 more
wiley   +1 more source

High‐Throughput Tn‐Seq Screens Identify Both Known and Novel Pseudomonas putida KT2440 Genes Involved in Metal Tolerance

open access: yesEnvironmental Microbiology, Volume 27, Issue 5, May 2025.
Exposure of Pseudomonas putida KT2440 to toxic metals activates genes PP_1663, PP_5002, PP_5337, and the two‐component system RoxSR, possibly linked to membrane integrity, FeS cluster maintenance, and DNA transcription, offering new insights into bacterial adaptation to metal tolerance.
Kevin Royet   +8 more
wiley   +1 more source

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