Results 271 to 280 of about 72,098 (338)

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Combined metabolome and transcriptome to analyze the regulatory network of key enzymes in the synthesis of senkirkine in Emilia sonchifolia. [PDF]

BMC Plant Biol
Yao J, Qin Y, Tu D, Huang Y, Liang L, Cai W, Huang M, Zhu X, Lao X.   +8 more
europepmc   +1 more source

Pseudotetraivprolide aus Pseudomonas entomophila liefern Einblicke in die Biosynthese von Detoxin/Rimosamid‐ähnlichen Anti‐Antibiotika

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Pseudotetraivprolid ist ein neuer Akteur unter den Detoxin/Rimosamid‐ähnlichen Naturstoffen. Die Biosynthese erfordert FabD aus dem Primärstoffwechsel und einen PipDFG‐Komplex für die Acetylierung im letzten Schritt – wodurch schließlich die anti‐antibiotische Wirkung entsteht.
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

Recent Progress in <i>N</i>-Acylethanolamine Research: Biological Functions and Metabolism Regulated by Two Distinct <i>N</i>-Acyltransferases: cPLA₂ε and PLAAT Enzymes. [PDF]

Int J Mol Sci
Uyama T, Sasaki S, Okada-Iwabu M, Murakami M.   +3 more
europepmc   +1 more source

Stereochemische Entschlüsselung der Strobilurin‐PKS enthüllt die komplexe biosynthetische Logik des iterativen Aufbaus eines EZE‐Triens

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Die iterative Strobilurin‐PKS baut ein bemerkenswertes EZE‐Trien auf, indem es seine S‐tereoselektvität während der Synthese variiert. Die stereoselektive 2R‐Methylierung des Triketid‐Intermediats durch die C‐terminale C‐Methyltransferase‐Domäne induziert die KR‐ und DH‐Domänen ihre native Stereoselektivität umzukehren und ein Z‐konfiguriertes ...
Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao, Russell J. Cox   +5 more
wiley   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Naringin Mitigates PEDV-Induced Intestinal Damage in Suckling Piglets by Modulating Inflammatory, Antiviral, and Metabolic and Transport Pathways. [PDF]

Biomolecules
Zhang Y, Li M, Li Z, Li Z, Wang L, Zhao D, Wu T, Yi D, Hou Y.   +8 more
europepmc   +1 more source

Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
Pseudotetraivprolide is a new player among the Detoxin/Rimosamide‐like natural products! Its biosynthesis requires FabD from primary metabolism and a PipDFG complex for final‐step acetylation – unlocking its anti‐antibotic activity. Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis ...
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

Regulatory network rewiring drives strain-specific lipid accumulation response in Chlorella sorokiniana under nutrient starvation. [PDF]

Plant J
Barrera-Duarte CC, Chávez Montes RA, Nájera-González HR, Lopez-Arredondo D.   +3 more
europepmc   +1 more source

Proximal Tubule‐Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Daiki Aomura, Takayuki Nimura, Kosuke Yamaka, Yosuke Yamada, Makoto Harada, Takero Nakajima, Takefumi Kimura, Koji Hashimoto, Hiroyuki Kanno, Motoko Yanagita, Frank J. Gonzalez, Naoki Tanaka, Yuji Kamijo   +12 more
wiley   +1 more source