Results 41 to 50 of about 24,285 (335)

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

Nature Communications, 2021
AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids.
Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J. Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang   +17 more
doaj   +1 more source

Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases [PDF]

, 2015
S-acylation is a major post-translational modification affecting several cellular processes and being particularly important for neuronal functions. This modification is catalysed by a family of transmembrane S-acyl-transferases that contain a conserved ...
Chamberlain, Luke H., Lemonidis, Kimon, Sanchez-Perez, Maria C.   +2 more
core   +1 more source

Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases

Journal of Pharmacological Sciences, 2009
Attenuating effects of peroxisome proliferators on the concentration of free arachidonic acid by inducing 1-acyl-2-lysophospholipid acyltransferases in the kidney were studied.
Tohru Yamazaki, Akihiko Hirose, Takeshi Sakamoto, Mari Okazaki, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima   +6 more
doaj   +1 more source

Functional characterization of a melon alcohol acyl-transferase gene family involved in the biosynthesis of ester volatiles. Identification of the crucial role of a threonine residue for enzyme activity [PDF]

, 2005
Volatile esters, a major class of compounds contributing to the aroma of many fruit, are synthesized by alcohol acyl-transferases (AAT). We demonstrate here that, in Charentais melon (Cucumis melo var.
A. Aggelis, A. Aharoni, A.-D. Bauchot, A.G. Perez, A.M. Dandekar, Alain Latché, B. St Pierre, B. St Pierre, B.G. Defilippi, B.G. Defilippi, C. Aubert, C. Sanz, Daniel Manríquez, E. Pichersky, F. Flores, F. Jeanmougin, F. Yahyaoui, Farid Regad, Francisco B. Flores, H. Shiota, H. Yoshimoto, I. Zabetakis, Islam El-Sharkawy, J. Beekwilder, J. D’Auria, J. Song, J.C. Beaulieu, J.P. Mattheis, Jean-Claude Pech, M. Guis, M. Harada, M. Shalit, M. Shalit, M.M. Bradford, Mondher Bouzayen, N. Dudareva, N. Dudareva, N. Dudareva, N.A. Mir, N.M.M. Paillard, P.K. Boss, R. Ayub, R. Medina-Suarez, R.D.M. Page, R.M. Beaudry, S. Elss, S. Lurie, S.F. Altschul, S.G. Wyllie, V. Homatidou, X. Fan, X. Ma, Y. Wang, Y.W. Nam   +53 more
core   +1 more source

Structure, mechanism, and inhibition of Hedgehog acyltransferase [PDF]

Molecular Cell, 2021
The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi-pass transmembrane enzyme Hedgehog acyltransferase (HHAT).
Coupland, Claire E., Andrei, Sebastian A., Ansell, T. Bertie, Carrique, Loic, Kumar, Pramod, Sefer, Lea, Schwab, Rebekka A., Byrne, Eamon F.X., Pardon, Els, Steyaert, Jan, Magee, Anthony I., Lanyon-Hogg, Thomas, Sansom, Mark S.P., Tate, Edward W., Siebold, Christian   +14 more
openaire   +5 more sources

Molecular and Genetic Regulation of Sensory Quality of Climacteric Fruit [PDF]

, 2004
The sensory quality of fruit has become a major criterion in making the purchasing decision by consumers. Breeding programs have mainly been directed, from the post-harvest stand point, towards improving shelf-life.
A. Latché, D. Manriquez, F.B. Flores, I. El-Sharkawy, J.C. Pech   +4 more
core   +1 more source

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Nature Communications, 2021
Double membrane vesicles (DMV) are used as replication organelles by several RNA viruses. Applying proteomics and lipidomics, Tabata and Prasad et al.
Keisuke Tabata, Vibhu Prasad, David Paul, Ji-Young Lee, Minh-Tu Pham, Woan-Ing Twu, Christopher J. Neufeldt, Mirko Cortese, Berati Cerikan, Yannick Stahl, Sebastian Joecks, Cong Si Tran, Christian Lüchtenborg, Philip V’kovski, Katrin Hörmann, André C. Müller, Carolin Zitzmann, Uta Haselmann, Jürgen Beneke, Lars Kaderali, Holger Erfle, Volker Thiel, Volker Lohmann, Giulio Superti-Furga, Britta Brügger, Ralf Bartenschlager   +25 more
doaj   +1 more source

Substrate selectivity in the zDHHC family of S-acyltransferases [PDF]

, 2017
S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a family of membrane-bound 'zDHHC' enzymes. S-acylation predominantly results in anchoring of soluble proteins to membrane compartments or in the trafficking of ...
Chamberlain, Luke H., Diez-Ardanuy, Cinta, Greaves, Jennifer, Kouskou, Marianna, Lemonidis, Kimon, Salaun, Christine   +5 more
core   +1 more source

Membrane Topology of Hedgehog Acyltransferase [PDF]

Journal of Biological Chemistry, 2015
Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzyme that mediates the covalent attachment of the 16-carbon fatty acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh). Palmitoylation of Shh by Hhat is critical for short and long range signaling.
Armine Matevossian, Marilyn D. Resh
openaire   +2 more sources

Systematic identification and expression profiles of the BAHD superfamily acyltransferases in barley (Hordeum vulgare)

Scientific Reports, 2022
BAHD superfamily acyltransferases play an important role in catalyzing and regulating secondary metabolism in plants. Despite this, there is relatively little information regarding the BAHD superfamily in barley.
Zhen Yuan, Hongliang Yang, Leiwen Pan, Wenhui Zhao, Lunping Liang, Anicet Gatera, Matthew R. Tucker, Dawei Xu   +7 more
doaj   +1 more source