Results 21 to 30 of about 2,318 (247)

Substrate recruitment by zDHHC protein acyltransferases

Open Biology, 2021
Protein palmitoylation is the post-translational attachment of fatty acids, most commonly palmitate (C16 : 0), onto a cysteine residue of a protein. This reaction is catalysed by a family of integral membrane proteins, the zDHHC protein acyltransferases (
Martin Ian P. Malgapo, Maurine E. Linder
doaj   +1 more source

Regulation of T cell function by protein S-acylation

Frontiers in Physiology, 2022
S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of
Savannah J. West, Savannah J. West, Darren Boehning, Askar M. Akimzhanov, Askar M. Akimzhanov   +4 more
doaj   +1 more source

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism

Journal of Lipid Research, 2015
The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG). Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of chylomicrons, which deliver metabolic fuels, essential fatty acids, and ...
Chi-Liang Eric Yen, David W. Nelson, Mei-I Yen   +2 more
doaj   +1 more source

Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

Nature Communications, 2022
How palmitoylated proteins specifically localize is not fully understood. Here, authors created the SwissKASH assay to visualize S-palmitoylation in cells and uncovered a striking substrate selectivity of acyltransferases at the core of this process.
Gonzalo P. Solis, Arghavan Kazemzadeh, Laurence Abrami, Jana Valnohova, Cecilia Alvarez, F. Gisou van der Goot, Vladimir L. Katanaev   +6 more
doaj   +1 more source

Characterisation of two alcohol acyltransferases from kiwifruit (Actinidia spp.) reveals distinct substrate preferences. [PDF]

, 2011
Volatile esters are key compounds of kiwifruit flavour and are formed by alcohol acyltransferases that belong to the BAHD acyltransferase superfamily.
Souleyre, Edwige J. F., Newcomb, Richard, Chervin, Christian, Marsh, Ken, Christian Chervin, Richard D. Newcomb, Edwige J.F. Souleyre, Marsh, Ken B., Catrin S. Günther, Günther, Catrin S., Newcomb, Richard D., Souleyre, Edwige J.F., Günther, Catrin, Ken B. Marsh   +13 more
core   +1 more source

Discovery and Engineering of Promiscuous Acyltransferases [PDF]

, 2021
Promiscuous acyltransferases enable transesterification reactions in bulk water by preferentially catalyzing acyl transfer over hydrolysis. Until recently, only a small number of promiscuous acyltransferases have been described in the literature ...
Godehard, Simon Peter
core   +1 more source

MOGAT2: A New Therapeutic Target for Metabolic Syndrome

Diseases, 2015
Metabolic syndrome is an ever-increasing health problem among the world’s population. It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus type II
Muhua Yang, Joseph T. Nickels
doaj   +1 more source

Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases

Nature Communications, 2022
Approaches for manipulating individual organelles are important for learning more about their functions. Here the authors report a tool utilising phospholipase A/acyltransferases (PLAATs) for rapid defunctionalisation of organelles through remodelling of
Satoshi Watanabe, Yuta Nihongaki, Kie Itoh, Toru Uyama, Satoshi Toda, Shigeki Watanabe, Takanari Inoue   +6 more
doaj   +1 more source

Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj   +1 more source

Acyl-CoA:Lysophospholipid Acyltransferases [PDF]

Journal of Biological Chemistry, 2009
Cell membranes contain several classes of glycerophospholipids, which have numerous structural and functional roles in the cells. Polyunsaturated fatty acids, including arachidonic acid and eicosapentaenoic acid, are located at the sn-2 (but not sn-1)-position of glycerophospholipids in an asymmetrical manner.
Hideo, Shindou, Takao, Shimizu
openaire   +2 more sources