Results 41 to 50 of about 12,733 (207)

Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower

Nature Communications, 2021
Biosynthetic pathway of chicoric acid in purple coneflower has not been fully elucidated, though the compound has been shown to have potential health benefits.
Rao Fu, Pingyu Zhang, Ge Jin, Lianglei Wang, Shiqian Qi, Yang Cao, Cathie Martin, Yang Zhang   +7 more
doaj   +1 more source

Rational Design for Enhanced Acyltransferase Activity in Water Catalyzed by the Pyrobaculum calidifontis VA1 Esterase

Microorganisms, 2021
Biocatalytic transesterification is commonly carried out employing lipases in anhydrous organic solvents since hydrolases usually prefer hydrolysis over acyl transfer in bulk water.
Amanda Staudt, Henrik Terholsen, Jasmin Kaur, Henrik Müller, Simon P. Godehard, Ivaldo Itabaiana, Ivana C. R. Leal, Uwe T. Bornscheuer   +7 more
doaj   +1 more source

Efficient Acylation of Sugars and Oligosaccharides in Aqueous Environment Using Engineered Acyltransferases

, 2021
A major challenge for the enzymatic synthesis of sugar esters is the low solubility of sugars in anhydrous, often toxic, organic solvents. We overcame this limitation by using acyltransferases for efficient acetylation of sugars in water.
Mihovilovic, Marko D.; orcid:, Müller, Henrik, Badenhorst, Christoffel P. S.; orcid:, Suster, Christoph; orcid:, Stanetty, Christian; orcid:, Godehard, Simon P.; orcid:, Bornscheuer, Uwe T.; orcid:   +6 more
core   +1 more source

Discovery and Engineering of Promiscuous Acyltransferases [PDF]

, 2021
Promiscuous acyltransferases enable transesterification reactions in bulk water by preferentially catalyzing acyl transfer over hydrolysis. Until recently, only a small number of promiscuous acyltransferases have been described in the literature ...
Godehard, Simon Peter
core  

In Vitro Analysis of Hedgehog Acyltransferase and Porcupine Fatty Acyltransferase Activities [PDF]

, 2019
Hedgehog and Wnt proteins are modified by covalent attachment of the fatty acids palmitate and palmitoleate, respectively. These lipid modifications are essential for Hedgehog and Wnt protein signaling activities and are catalyzed by related, but distinct fatty acyltransferases: Hedgehog acyltransferase (Hedgehog) and Porcupine (Wnt).
James John, Asciolla, Kalpana, Rajanala, Marilyn D, Resh   +2 more
openaire   +2 more sources

Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases

Journal of Pharmacological Sciences, 2009
Attenuating effects of peroxisome proliferators on the concentration of free arachidonic acid by inducing 1-acyl-2-lysophospholipid acyltransferases in the kidney were studied.
Tohru Yamazaki, Akihiko Hirose, Takeshi Sakamoto, Mari Okazaki, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima   +6 more
doaj   +1 more source

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

Nature Communications, 2021
AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids.
Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J. Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang   +17 more
doaj   +1 more source

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Nature Communications, 2021
Double membrane vesicles (DMV) are used as replication organelles by several RNA viruses. Applying proteomics and lipidomics, Tabata and Prasad et al.
Keisuke Tabata, Vibhu Prasad, David Paul, Ji-Young Lee, Minh-Tu Pham, Woan-Ing Twu, Christopher J. Neufeldt, Mirko Cortese, Berati Cerikan, Yannick Stahl, Sebastian Joecks, Cong Si Tran, Christian Lüchtenborg, Philip V’kovski, Katrin Hörmann, André C. Müller, Carolin Zitzmann, Uta Haselmann, Jürgen Beneke, Lars Kaderali, Holger Erfle, Volker Thiel, Volker Lohmann, Giulio Superti-Furga, Britta Brügger, Ralf Bartenschlager   +25 more
doaj   +1 more source

Systematic identification and expression profiles of the BAHD superfamily acyltransferases in barley (Hordeum vulgare)

Scientific Reports, 2022
BAHD superfamily acyltransferases play an important role in catalyzing and regulating secondary metabolism in plants. Despite this, there is relatively little information regarding the BAHD superfamily in barley.
Zhen Yuan, Hongliang Yang, Leiwen Pan, Wenhui Zhao, Lunping Liang, Anicet Gatera, Matthew R. Tucker, Dawei Xu   +7 more
doaj   +1 more source

Identification of Three Genes Encoding for the Late Acyltransferases of Lipid A in Cronobacter sakazakii

Marine Drugs, 2013
Lipid A, the hydrophobic anchor of lipopolysaccharide, is an essential component in the outer membrane of most Gram-negative bacteria. Food-borne pathogen Cronobacter sakazakii synthesizes two lipid A species, differing by the length of the secondary ...
Wen Guo, Chan Zhang, Xiaoyuan Wang, Guanjun Tao, Liping Cai, Yanyan Li   +5 more
doaj   +1 more source