Results 31 to 40 of about 12,733 (207)

Acyltransferases as Tools for Polyketide Synthase Engineering

Antibiotics, 2018
Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll, Wolfgang Wohlleben   +1 more
doaj   +1 more source

Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases

Nature Communications, 2022
Approaches for manipulating individual organelles are important for learning more about their functions. Here the authors report a tool utilising phospholipase A/acyltransferases (PLAATs) for rapid defunctionalisation of organelles through remodelling of
Satoshi Watanabe, Yuta Nihongaki, Kie Itoh, Toru Uyama, Satoshi Toda, Shigeki Watanabe, Takanari Inoue   +6 more
doaj   +1 more source

Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj   +1 more source

Acyltransferases in Protease’s Clothing [PDF]

The Plant Cell, 2000
One of the most intriguing questions in plant secondary metabolism concerns the evolution of the genes required for the rapid diversification of plant chemistry. In particular, the mechanisms are beginning to be understood by which evolution recruits primary and intermediary metabolism genes ...
openaire   +2 more sources

Pathways of Lipid Metabolism in Marine Algae, Co-Expression Network, Bottlenecks and Candidate Genes for Enhanced Production of EPA and DHA in Species of Chromista

Marine Drugs, 2013
The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health has received more focus the last decades, and the global consumption of n-3 LC-PUFA has increased.
Alice Mühlroth, Keshuai Li, Gunvor Røkke, Per Winge, Yngvar Olsen, Martin F. Hohmann-Marriott, Olav Vadstein, Atle M. Bones   +7 more
doaj   +1 more source

Recent Insights and Future Perspectives on Promiscuous Hydrolases/Acyltransferases

, 2021
Promiscuous hydrolases/acyltransferases have attracted attention for their ability to efficiently catalyze selective transacylation reactions in water to produce esters, thioesters, amides, carbonates, and carbamates.
Badenhorst, Christoffel P. S., Godehard, Simon P., Bornscheuer, Uwe T., Uwe T. Bornscheuer, Müller, Henrik, Christoffel P. S. Badenhorst, Henrik Terholsen, Terholsen, Henrik, Simon P. Godehard, Henrik Müller   +9 more
core   +1 more source

Identification and characterization of piperine synthase from black pepper, Piper nigrum L.

Communications Biology, 2021
Schnabel et al. identify and characterize piperine synthase in developing black pepper fruits which catalyses the formation of piperine from piperoyl coenzyme A and piperidine.
Arianne Schnabel, Benedikt Athmer, Kerstin Manke, Frank Schumacher, Fernando Cotinguiba, Thomas Vogt   +5 more
doaj   +1 more source

Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays

Journal of Lipid Research, 2013
Click chemistry is evolving as a powerful tool in biological applications because it allows the sensitive and specific detection of compounds with alkyne or azido groups.
Anne Gaebler, Robin Milan, Leon Straub, Dominik Hoelper, Lars Kuerschner, Christoph Thiele   +5 more
doaj   +1 more source

The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

Nature Communications, 2021
During phosphatidylcholine (PC) remodeling re-acylation is catalyzed by lysophosphatidylcholine acyltransferases (LPCAT). Here, the authors present crystal and cryo-EM structures of chicken LPCAT3 in the apo-, acyl donor-bound and acyl receptor-bound ...
Qing Zhang, Deqiang Yao, Bing Rao, Liyan Jian, Yang Chen, Kexin Hu, Ying Xia, Shaobai Li, Yafeng Shen, An Qin, Jie Zhao, Lu Zhou, Ming Lei, Xian-Cheng Jiang, Yu Cao   +14 more
doaj   +1 more source

S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis

Nature Communications, 2021
S-acylation is a reversible protein post-translational modification that often regulates protein function at the plasma membrane. Here the authors show that an Arabidopsis extracellular ATP receptor P2K1 mediates phosphorylation of two S-acyltransferases
Dongqin Chen, Fengsheng Hao, Huiqi Mu, Nagib Ahsan, Jay J. Thelen, Gary Stacey   +5 more
doaj   +1 more source