Results 71 to 80 of about 2,318 (247)

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

ACYLTRANSFERASES AND METHODS OF USING [PDF]

, 2019
Provided herein are novel acyltransferases and methods of using such novel acyltransferases in making medium - chain fatty ...
Cahoon, Edgar, Kim, Hae Jin, Iskandarov, Umidjon, Collins-Silva, Jillian   +3 more
core  

The RXR Motifs of Select Acyltransferases Control Extender Unit Specificity.

, 2014
The RXR Motifs of Select Acyltransferases Control Extender Unit Specificity.
Brian M. Kevany (650106), Michael G. Thomas (650108), Hyunjun Park (650105), David H. Dyer (650107), Katrina T. Forest (266995)   +4 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Promiscuous acyltransferases for ester and amide synthesis in aqueous solution [PDF]

Hydrolases are well-known for hydrolyzing esters, amides, carbamates, peptides, or acid anhydrides in the presence of water. However, some of them are also capable of catalyzing the reverse reaction (condensation) under certain conditions in aqueous ...
Meinert, Hannes, Bornscheuer, Uwe T., Cziegler, Clemens, Baumert, Benjamin, Terholsen, Henrik, Bayer, Thomas   +5 more
core   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source