Results 71 to 80 of about 1,706,692 (287)
Acta Medica Iranica, 2016 Alzheimer’s disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This
Hamid Sohanaki +3 more
doaj
Brain and BehaviorBackground Alzheimer's disease (AD) is a complex and common neurodegenerative disorder. The present study aimed to investigate the potential effects of selegiline (SEL) on various aspects of memory performance, anxiety, and oxidative stress in an AD rat ...
Behnam Mohamadpour +4 more
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Do intrusive in-app ads in branded mobile applications influence Gen Z users' behavioural responses?
Acta PsychologicaBranded apps have emerged as an important component of contemporary mobile marketing strategies, enabling organizations to strengthen customer engagement, enhance user experiences, and cultivate long-term brand loyalty. While mobile apps often rely on in-
Chetana Balakrishna Maddodi +1 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Frontiers in PsychiatryBackgroundAdjustment Disorder (AD) is a psychological condition that arises as a response to identifiable stressors, leading to emotional distress and functional impairment.
Tarık Sağlam
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Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
Frontiers in Behavioral Neuroscience, 2015 There is increasing evidence that brain-derived neurotrophic factor (BDNF) plays a crucial role in AD pathology. A number of studies demonstrated that AD patients exhibit reduced BDNF levels in the brain and the blood serum, and in addition, several ...
Laura ePsotta +9 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Relationship between efficacy and preferential targeting of soluble Aβ aggregates
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Amyloid beta (Aβ)‐directed antibodies have shown varying degrees of efficacy against Alzheimer's disease (AD). This study explored the relationship between targeting of Aβ molecular species and therapeutic efficacy/adverse effects.
Johanne M. Kaplan +6 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source