Results 101 to 110 of about 34,322 (240)

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Targeted treatment of psoriasis with adalimumab: a critical appraisal based on a systematic review of the literature

Biologics: Targets & Therapy, 2009
Jochen Schmitt, Gottfried WozelDepartment of Dermatology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, GermanyAbstract: Psoriasis is a chronic inflammatory disease affecting 2% to 3% of the population in Western countries ...
Jochen Schmitt, Gottfried Wozel
doaj  

Impact of Prior Biologic Mechanism of Action on Anti‐TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide ENEIDA registry study, anti‐TNF therapy after prior exposure to a different biologic mechanism of action showed reduced treatment durability in inflammatory bowel disease, with a particularly marked impact in ulcerative colitis, where short‐ and long‐term clinical effectiveness was also lower. ABSTRACT Background The expanding use of
Carmen Yagüe Caballero, Santiago García López, Ana Royo Esteban, Laura Figueras Panillo, Pilar Nos, Luisa de Castro, M. Dolores Martín‐Arranz, Manuel Barreiro‐de Acosta, Elena Ricart, Ruth de Francisco, Eva Iglesias, Antonio Giordano, Pilar Varela, Iago Rodríguez‐Lago, Montserrat Rivero, Beatriz Sicilia, Merce Navarro‐Llavat, Isabel Vera, Carles Suria, Jordi Guardiola, Jesús Barrio, Margalida Calafat, Ana Gutiérrez, Xavier Calvet, David Rafael de la Cruz, Francisco Mesonero, Cristina Martínez Pascual, Javier P. Gisbert, Carla J. Gargallo‐Puyuelo, David Monfort i Miquel, Mónica Sierra, Laura Arranz, Cristina Rodríguez‐Gutiérrez, Rufo Lorente, Fernando Bermejo, Lucía Márquez‐Mosquera, Gisela Torres Vicente, José Lázaro Pérez‐Calle, José M. Huguet, Laura Ramos, Ángel Ponferrada‐Díaz, Daniel Ceballos, Mª. Teresa Diz‐Lois Palomares, Eva Sesé Abizanda, Pablo Vega, Ramón Pajares, Javier Santos Fernández, Elena Betoré, David Busquets, Olga Merino, Carlos Martínez‐Flores, Yamile Zabana, Manuela Josefa Sampedro González, Jone Ortiz de Zarate, Ana Fuentes Coronel, Empar Sainz Arnau, Daniel Carpio, Nuria Jiménez, Ignacio Marín‐Jiménez, Luis Bujanda, Raquel Camargo Camero, Martín Irabien, María Abanades Tercero, Benito Velayos Jiménez, Pilar Robledo Andres, Ana María Trapero, Pedro G. Delgado‐Guillena, Luís Hernández Villalba, Margarita Menacho, Nuria Rull Murillo, Carles Leal, Cristina Alba, Rosa Gómez Espín, Alfredo J. Lucendo, Manuel Van Domselaar, Laura García Alles, Eduardo Iyo Miyashiro, Ana Crespo Catalá, Pau Gilabert, Daniel Martín Rodríguez, Víctor Manuel Navas‐López, María Calvo Iñiguez, Daniel Ginard, Teresa Martínez Pérez, Eugeni Domènech, Diego Casas Deza   +85 more
wiley   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Are Ocular Markers of Sun Exposure Associated With Skin Cancer? A Cross‐Sectional Analysis of the Busselton Healthy Ageing Study

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Higher past sun or ultraviolet radiation exposure increases the risk of skin cancer and three common ocular findings: pterygium, conjunctival ultraviolet autofluorescence (CUVAF) and myopia. We investigated whether ocular markers of past sun exposure are associated with a history of skin cancer.
Gareth Lingham, Vinay Kumar Nilagiri, Holly Brown, Chrianna Bharat, Samantha S. Y. Lee, Maria Franchina, Michael Hunter, Kevin Murray, David Alonso‐Caneiro, Catherine M. Olsen, David C. Whiteman, David A. Mackey   +11 more
wiley   +1 more source

Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease

Biologics: Targets & Therapy, 2017
Hitoshi Amano,1 Reikei Matsuda,1 Tomohiko Shibata,2 Daisuke Takahashi,1 Shinichiro Suzuki3 1Department of Gastroenterology, Fujisawa Shonandai Hospital, Fujisawa, 2Division of Rheumatology, Department of Internal Medicine, St Marianna University School ...
Amano H, Matsuda R, Shibata T, Takahashi D, Suzuki S   +4 more
doaj  

Economic burden of hidradenitis suppurativa based on healthcare resource utilization: German claims data analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease affecting approximately 0.1% of the German population. Patients with HS require substantial healthcare resource utilization. This study aimed to assess the economic burden associated with HS in Germany.
Falk G. Bechara, Tanja Tran, Sandeep Kiri, Romy Bley, Kathrin Schlüter, Claudia Grellmann, Sima Melnik, Sylke Schneider‐Burrus   +7 more
wiley   +1 more source

Impact of adalimumab treatment on impairment of non‐professional activities in psoriasis patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non‐professional activities. This study investigates the effects of long‐term treatment with adalimumab regarding work ability, non‐professional activities, and health‐related quality of life in a large real‐word ...
Georgios Kokolakis, Sandra Philipp, Thomas Mosch, Björn Fritz, Robert Sabat   +4 more
wiley   +1 more source