Results 221 to 230 of about 66,826 (280)

Serum Proteomic Profiling Uncovers Dysregulated Keratinisation and Immune‐Related Pathways in Hidradenitis Suppurativa

Experimental Dermatology, Volume 35, Issue 4, April 2026.
ABSTRACT Hidradenitis suppurativa (HS) is an autoinflammatory keratinisation disease affecting the pilosebaceous unit and hallmarked by a complex and multifactorial pathogenesis. Although genomic and transcriptomic investigations have substantially advanced our understanding of key mechanisms underlying HS pathogenesis, proteomic studies remain limited,
Chiara Moltrasio, Sara Roncarà, Blendi Ura, Elena Maria Nardacchione, Eduardo Sommella, Ronald Moura, Federica Derlino, Angelo Valerio Marzano, Sergio Crovella, Paola Maura Tricarico   +9 more
wiley   +1 more source

Higher Anti-Drug Antibody Levels to Anti-Tumor Necrosis Factor Therapies Are Associated with Treatment Failure in Patients with Inflammatory Bowel Disease. [PDF]

J Clin Med
Saraga A, Deyhim T, Gade A, Geeganage G, Soliman M, Rothschild NDV, Zullow S, Rabinowitz LG, Grossberg LB, Cheifetz AS, Papamichael K.   +10 more
europepmc   +1 more source

Tuberculosis of the tongue in a patient with rheumatoid arthritis treated with methotrexate and adalimumab. [PDF]

, 2014
Assante LR, Barra E, BOCCHINO, MARIALUISA, Ferrara G, SANDUZZI ZAMPARELLI, ALESSANDRO, Zuccarini G   +5 more
core  

Molecular Changes Induced by Carbon Dioxide Laser in Hailey‐Hailey Disease: A Potential Mechanism Underlying Treatment Efficacy

International Journal of Dermatology, Volume 65, Issue 4, Page 797-805, April 2026.
ABSTRACT Introduction Hailey‐Hailey disease (HHD) is a rare genodermatosis caused by mutations in the ATP2C1 gene that codes for SPCA1, a calcium transporter in the epidermis. HHD impairs quality of life, and no curative treatment exists. Methods To confirm the efficacy and safety of CO2 laser in HHD, we conducted a randomized, prospective, controlled ...
Javier Antoñanzas, Agustín España, Ana Gorostidi, Ana Patiño‐García, Marcos J. Araúzo‐Bravo, Daniela Gerovska, Rafael Salido‐Vallejo, Leyre Aguado‐Gil   +7 more
wiley   +1 more source

Cost-effectiveness of different strategies with biologics for the treatment of moderate to severe Crohn's disease in China. [PDF]

World J Gastroenterol
Wu Y, Tao LB, Liu C, Wang FX, Yan Y, Sun S.   +5 more
europepmc   +1 more source

Two‐Stage Surgical Management of Anogenital Hidradenitis Suppurativa in Patients on Biologic Therapy: A Retrospective Case Series

International Wound Journal, Volume 23, Issue 4, April 2026.
ABSTRACT Hidradenitis suppurativa is a chronic inflammatory skin disorder causing painful nodules, abscesses and scarring, with the anogenital region presenting particular functional and reconstructive challenges. Although biologic therapy is commonly used in moderate to severe disease, its limitations highlight the role of surgery in advanced cases ...
Nino Fuchs, Lucija Pavljak, Dinko Hauptman, Marko Mance   +3 more
wiley   +1 more source

Anti-TNF Therapies Promote a Proximal-to-Distal Healing Pattern in Moderate-to-Severe Ulcerative Colitis. [PDF]

Inflamm Bowel Dis
Wong ECL, Dulai PS, Marshall JK, Jairath V, Reinisch W, Narula N.   +5 more
europepmc   +1 more source

Efficacy and safety of biologics for hidradenitis suppurativa: A network meta‐analysis of phase III trials

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 4, Page 637-645, April 2026.
Data from 2731 patients with hidradenitis suppurativa (HS) treated with biologics for 12–16 weeks in phase III randomized controlled trials (RCT) were included in a network meta‐analysis (NMA). Adalimumab showed the highest efficacy in achieving a clinical HS response 50 (HiSCR50) and the lowest incidence of adverse events (AE).
Laura Calabrese, Alessandra Cartocci, Pietro Rubegni, Lars E. French, Benjamin Kendziora   +4 more
wiley   +1 more source

Real-Life Use of Subcutaneous Biologicals and JAK Inhibitors in IBD Maintenance Therapy: Treatment Continuation, Switching Patterns, and Concomitant Medications. [PDF]

Clin Exp Gastroenterol
Koivusalo M, Jokelainen J, Huhtinen A, Kovac B, Silvola S, Torvinen S, Ylisaukko-Oja T, Arkkila P.   +7 more
europepmc   +1 more source

Towards the development of upgrade criteria for the treatment of hidradenitis suppurativa with biologics

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 4, Page 658-669, April 2026.
Forty‐three HS specialists from 22 European countries reported adherence to HS guidelines and use of antibiotics before biologics despite limited efficacy and rapid relapse (49% within 1–3 months). Seventy‐nine per cent supported short‐term biologics for severe Hurley I disease.
Georgios Nikolakis, Erkan Alpsoy, Monika Arenbergerova, Falk G. Bechara, Farida Benhadou, Joana Cabete, Raffaele Dante Caposiena Caro, Giovanni Damiani, Maia Delage Toriel, Veronique Del Marmol, Valentina Dini, Evangelos J. Giamarellos‐Bourboulis, Katalin Glasenhardt, Philippe Guillem, Ariela Hafner, Evgeniya Hristakieva, John R. Ingram, Vaiva Jarienè, Gregor B. E. Jemec, Niamh Kearney, Brian Kirby, Natalia Kirsten, Piotr K. Krajewski, Vesta Kucinskiene, Aikaterini I. Liakou, Flavia Manzo Margiotta, Angelo V. Marzano, Antonio Martorell, Lukasz Matusiak, Dillon Mintoff, Alejandro Molina Leyva, Francesca Prignano, Tadas Raudonis, Hans Christian Ring, Marco Romanelli, Samed Şahin, Ditte M. L. Saunte, Linnea Thorlacius, Thrasyvoulos Tzellos, Hessel H. Van Der Zee, Kelsey Van Straalen, Christos C. Zouboulis   +41 more
wiley   +1 more source