Results 121 to 130 of about 22,445 (222)

Molecular changes associated with escitalopram response in a stress-based model of depression [PDF]

, 2018
Converging evidence points at hypothalamus-pituitary-adrenal (HPA) axis hyperactivity and neuroinflammation as important factors involved in the etiopathogenesis of major depressive disorder (MDD) and in therapeutic efficacy of antidepressants.
Alboni, Silvia, Benatti, Cristina, Blom, Johanna Maria Catharina, Brunello, Nicoletta, Mendlewicz, Julien, Tascedda, Fabio   +5 more
core   +1 more source

ADAM17 inhibition enhances platinum efficiency in ovarian cancer

Oncotarget, 2018
Chemotherapeutic resistance evolves in about 70 % of ovarian cancer patients and is a major cause of death in this tumor entity. Novel approaches to overcome these therapeutic limitations are therefore highly warranted. A disintegrin and metalloprotease 17 (ADAM17) is highly expressed in ovarian cancer and required for releasing epidermal growth factor
Hedemann, Nina, Rogmans, Christoph, Sebens, Susanne, Wesch, Daniela, Reichert, Manuel, Schmidt-Arras, Dirk, Oberg, Hans-Heinrich, Pecks, Ulrich, van Mackelenbergh, Marion, Weimer, Jörg, Arnold, Norbert, Maass, Nicolai, Bauerschlag, Dirk O.   +12 more
openaire   +3 more sources

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE [PDF]

, 2018
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases.
Adrain, Colin, Bileck, Andrea, Bolado, Alfonso, Brezinova, Jana, Burbridge, Emma, Cavadas, Miguel, Clancy, Danielle, Collis, Blanka, Gerner, Christopher, Hu, Tianyi, Martin, Seamus J, Naegele, Heike, Oikonomidi, Ioanna, Steinberg, Florian, Strisovsky, Kvido, Sullivan, Graeme, Von Kriegsheim, Alex   +16 more
core   +2 more sources

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence. [PDF]

, 2016
Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive.
Alajati, A., Alimonti, A., Arribas, A., Bertoni, F., Chen, J., D'Antuono, R., Delaleu, N., Dimitrov, M., Fraering, P., Gerber, H., Gnetti, L., Losa, M., Nepveu, A., Pasquini, E., Perciato, M.L., Pinton, S., Revandkar, A., Rinaldi, A., Toso, A.   +18 more
core   +2 more sources

Exogenous nitric oxide inhibits shedding of ADAM17 substrates.

Acta Biochimica Polonica, 2009
Both ADAM17, the secretase responsible for the shedding of ectodomains of numerous membrane proteins including TNF and its receptors, as well as nitric oxide synthesized by inducible nitric oxide synthase play regulatory roles in inflammation and tumor progression.
Bzowska, Monika, Stalińska, Krystyna, Mężyk-Kopeć, Renata, Wawro, Karolina, Duda, Katarzyna, Das, Sudipta, Bereta, Joanna   +6 more
openaire   +4 more sources

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Platelets, 2017
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane “molecular scissors” which proteolytically cleave, or shed, the extracellular regions of other transmembrane proteins.
Alexandra L. Matthews, Peter J. Noy, Jasmeet S. Reyat, Michael G. Tomlinson   +3 more
doaj   +1 more source

Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution

Heliyon
Background: The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be ...
Ying Lin, Ming Chen, Xuelian Zhu, xiaoya cui, Suyu Sun, Xingzhong Hu   +5 more
doaj   +1 more source

Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells [PDF]

, 2006
Hepatocellular carcinoma is a major cause of cancer-related deaths. Current treatments are not effective, and the identification of relevant pathways and novel therapeutic targets are much needed.
Avila, M.A. (Matías Antonio), Berasain, C. (Carmen), Castillo, J. (Josefa), Erroba, E. (Elena), Lee, D.C. (David C.), Perugorria, M.J. (María J.), Prieto, J. (Jesús), Santamaria, M. (Mónica)   +7 more
core