A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. [PDF]
PLoS ONE, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Emanuela Leonardi +5 more
doaj +6 more sources
Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review [PDF]
Current Issues in Molecular Biology, 2023 Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role
Agnieszka Kalita +2 more
doaj +2 more sources
Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder [PDF]
Current Issues in Molecular BiologyBackground: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto +6 more
doaj +2 more sources
Conservation and divergence of ADAM family proteins in the
BMC Evolutionary Biology, 2010 Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Shah Anoop +6 more
doaj +5 more sources
Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation [PDF]
Cell Communication and SignalingBackground Endothelial cells are constantly exposed to mechanical forces generated by blood flow regulating endothelial homeostasis. Pathological events such as vascular injury or thrombus formation alter these forces, which are sensed by endothelial ...
Alessa Pabst +7 more
doaj +2 more sources
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview [PDF]
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
doaj +3 more sources
ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis [PDF]
BMB Reports, 2013 The ADAM and ADAMTS families, also called adamalysinsbelong to an important group of extracellular matrix proteins.The ADAMs family belong to both the transmembrane andsecreted proteins, while ADAMTS family only containssecreted forms.
Leszczynski Przemyslaw +3 more
doaj +5 more sources
Adaptive gradient scaling: integrating Adam and landscape modification for protein structure prediction [PDF]
BMC BioinformaticsBackground Protein structure prediction is one of the most important scientific problems, on the one hand, it is one of the NP-hard problems, and on the other hand, it has a wide range of applications including drug discovery and biotechnology ...
Vitalii Kapitan, Michael Choi
doaj +2 more sources
Revista de la Facultad de Medicina Humana, 2021 Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of
Clarisa Carolina Arrascue Vega +4 more
doaj +1 more source
Role of ADAM and ADAMTS proteases in pathological tissue remodeling
Cell Death Discovery, 2023 Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang +3 more
doaj +1 more source