Conservation and divergence of ADAM family proteins in the
BMC Evolutionary Biology, 2010 Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Shah Anoop +6 more
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A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. [PDF]
PLoS ONE, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Emanuela Leonardi +5 more
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Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review [PDF]
Current Issues in Molecular Biology, 2023 Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role
Agnieszka Kalita +2 more
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Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder [PDF]
Current Issues in Molecular BiologyBackground: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto +6 more
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ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview [PDF]
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
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ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment [PDF]
Cancers, 2021 The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells ...
Nathalie Théret +4 more
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Polymeric ADAM Protein Mimics Interrogate Mammalian Sperm–Egg Binding [PDF]
ChemBioChem, 2009 AbstractROMPing with the ADAMs family: The sperm‐surface display of egg adhesion proteins was investigated using multivalent polymer sperm mimics. Ruthenium‐catalyzed ring opening metathesis polymerization (ROMP) was used to synthesize heterovalent polymers.magnified imageThe sperm proteins ADAM2 and ADAM3, members of the ADAM family of proteins, have ...
Younjoo Lee, Nicole S. Sampson
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ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer [PDF]
Tumor Biology, 2017 FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and FHL2 deficiency
Laurine Verset +7 more
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ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage [PDF]
Journal of Biological Chemistry, 2004 ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification ...
Roopali Roy +4 more
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ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis [PDF]
BMB Reports, 2013 The ADAM and ADAMTS families, also called adamalysinsbelong to an important group of extracellular matrix proteins.The ADAMs family belong to both the transmembrane andsecreted proteins, while ADAMTS family only containssecreted forms.
Leszczynski Przemyslaw +3 more
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