Results 11 to 20 of about 75,759 (281)
ADAM and ADAMTS Proteases in Hepatic Disorders
Journal of Renal and Hepatic Disorders, 2019 Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the ...
Dirk Schmidt-Arras +2 more
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Reproductive Biology and Endocrinology, 2011 Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction.
Bonet Sergi +6 more
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ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment [PDF]
Cancers, 2021 The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells ...
Theret, Nathalie +4 more
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Evolutionary divergence and functions of the
Human Genomics, 2009 The 'A-disintegrin and metalloproteinase' (ADAM) and 'A-disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) genes make up two similar, yet distinct, gene families.
Brocker Chad N +2 more
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Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation [PDF]
Cell Communication and SignalingBackground Endothelial cells are constantly exposed to mechanical forces generated by blood flow regulating endothelial homeostasis. Pathological events such as vascular injury or thrombus formation alter these forces, which are sensed by endothelial ...
Alessa Pabst +7 more
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European Journal of Cell Biology, 2011 ADAM metalloproteases are membrane bound glycoproteins that control many biological processes during development and differentiation, mainly by acting as ectodomain sheddases. The Drosophila genome contains five genes that code for classical ADAM proteins which are characterized by a highly conserved domain structure with the respective catalytic ...
Heiko Meyer +2 more
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Adam13 interacts with large protein complexes to regulate histone modification and gene expression [PDF]
Frontiers in Cell and Developmental BiologyCranial neural crest (CNC) cells are a key stem cell like tissue that contribute to most of the facial structures in vertebrates. A disintegrin and metalloproteinase (ADAM) family of proteins is essential for the induction and migration of the CNC.
Ankit Pandey +10 more
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Revista de la Facultad de Medicina Humana, 2021 Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of
Clarisa Carolina Arrascue Vega +4 more
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Role of ADAM and ADAMTS proteases in pathological tissue remodeling
Cell Death Discovery, 2023 Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang +3 more
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ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages
Journal of Immunology Research, 2022 A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang +9 more
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