Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review [PDF]
Current Issues in Molecular Biology, 2023 Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role
Agnieszka Kalita +2 more
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A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. [PDF]
PLoS ONE, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Emanuela Leonardi +5 more
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Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder [PDF]
Current Issues in Molecular BiologyBackground: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto +6 more
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Conservation and divergence of ADAM family proteins in the
BMC Evolutionary Biology, 2010 Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Shah Anoop +6 more
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ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis [PDF]
BMB Reports, 2013 The ADAM and ADAMTS families, also called adamalysinsbelong to an important group of extracellular matrix proteins.The ADAMs family belong to both the transmembrane andsecreted proteins, while ADAMTS family only containssecreted forms.
Leszczynski Przemyslaw +3 more
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ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview [PDF]
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
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ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage [PDF]
Journal of Biological Chemistry, 2004 ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification ...
Roopali Roy +2 more
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Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes [PDF]
Cardiovascular Diabetology, 2007 Aims Type 2 diabetes is characterised by increased plasma concentrations of pro-inflammatory cytokines [such as tumour necrosis factor – alpha; TNF-α] and soluble forms of adhesion molecules involved in leukocyte – endothelial interactions.
Dozio Nicoletta +4 more
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ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer [PDF]
Tumor Biology, 2017 FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and FHL2 deficiency
Laurine Verset +7 more
doaj +2 more sources
Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation [PDF]
Cell Communication and SignalingBackground Endothelial cells are constantly exposed to mechanical forces generated by blood flow regulating endothelial homeostasis. Pathological events such as vascular injury or thrombus formation alter these forces, which are sensed by endothelial ...
Alessa Pabst +7 more
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