Results 31 to 40 of about 68,067 (282)

Snake venom disintegrins update: insights about new findings [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine, present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae, Elapidae, and Colubridae.
Gabriela de Oliveira Almeida, Isadora Sousa de Oliveira, Eliane Candiani Arantes, Suely Vilela Sampaio   +3 more
doaj   +1 more source

ADAM-15 Disintegrin-Like Domain Structure and Function

Toxins, 2010
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu, Mike Scully, Vijay Kakkar, Xinjie Lu   +3 more
doaj   +1 more source

Identification of ADAM 31: A Protein Expressed in Leydig Cells and Specialized Epithelia* [PDF]

Endocrinology, 2000
A family of proteins containing a disintegrin and metalloproteinase domain (ADAMs) has been identified recently. Here, we report the identification of a novel member of the ADAM protein family from mouse. This protein is designated ADAM 31. The complementary DNA sequence of ADAM 31 predicts a transmembrane protein with metalloproteinase, disintegrin ...
Limin Liu, Jeffrey W. Smith
openalex   +3 more sources

Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (sus domesticus) spermatozoa during epididymal maturation

Reproductive Biology and Endocrinology, 2011
Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction.
Bonet Sergi, Puigmulé Marta, Gatti Jean-Luc, Dacheux Jean-Louis, Guyonnet Benoît, Fàbrega Anna, Pinart Elisabeth   +6 more
doaj   +1 more source

Role of hypoxia-related proteins in adenoid cystic carcinoma invasion

Diagnostic Pathology, 2020
Background Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity.
Raíssa Pinheiro de Mendonça, Giordanna Pereira Chemelo, Geovanni Pereira Mitre, Dimitra Castelo Branco, Natacha Malu Miranda da Costa, Fabrício Mesquita Tuji, Maria Sueli da Silva Kataoka, Ricardo Alves Mesquita, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +9 more
doaj   +1 more source

ADAM and ADAMTS Proteases in Hepatic Disorders

Journal of Renal and Hepatic Disorders, 2019
Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the ...
Dirk Schmidt-Arras, Julia Bolik, Janina EE Tirnitz-Parker   +2 more
doaj   +1 more source

ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1

BMC Cancer, 2018
Background A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied
Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang, Guanzhen Yu   +6 more
doaj   +1 more source

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site

Toxins, 2023
A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa   +6 more
doaj   +1 more source

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State

Membranes, 2022
A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang, Simone Bonelli, Matteo Calligaris, Anna Paola Carreca, Stephan A. Müller, Stefan F. Lichtenthaler, Linda Troeberg, Simone D. Scilabra   +7 more
doaj   +1 more source

Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]

PLoS ONE, 2016
The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi, Sora Jin, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Suyeon Jeon, Zee Yong Park, Kang-Jin Jung, Kwangsung Park, Chunghee Cho   +10 more
doaj   +1 more source