Current Issues in Molecular Biology, 2023 Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role
Agnieszka Kalita +2 more
doaj +3 more sources
ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis [PDF]
BMB Reports, 2013 The ADAM and ADAMTS families, also called adamalysinsbelong to an important group of extracellular matrix proteins.The ADAMs family belong to both the transmembrane andsecreted proteins, while ADAMTS family only containssecreted forms.
Leszczynski Przemyslaw +3 more
doaj +3 more sources
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. [PDF]
PLoS ONE, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Emanuela Leonardi +5 more
doaj +3 more sources
Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (
Reproductive Biology and Endocrinology, 2011 Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction.
Bonet Sergi +6 more
doaj +2 more sources
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
doaj +3 more sources
ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer
Tumor Biology, 2017 FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and FHL2 deficiency
Laurine Verset +7 more
doaj +2 more sources
Detection of the ADAM Proteins in the Ejaculated Bovine Sperm [PDF]
, 2022 The current study aimed to detect specific types of ADAM proteins in the bovine sperm. Histology study of tissue of male reproduction was involved with testis, head, body, and the tail of the epididymis.
Yassin, A. (Asseel) +2 more
core +2 more sources
Role of ADAM and ADAMTS proteases in pathological tissue remodeling
Cell Death Discovery, 2023 Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang +3 more
doaj +1 more source
ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages
Journal of Immunology Research, 2022 A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 A disintegrin and metalloproteinase (ADAM) family of proteins play versatile roles in cancer development and progression. In the present study, we investigated the role of ADAM proteins in colorectal cancer (CRC) cell migration and invasion focusing on ...
Lina Sun +9 more
doaj +1 more source