Results 21 to 30 of about 2,469,099 (110)
Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions. [PDF]
PLoS ONE, 2015 A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a ...
Iivari Kleino +4 more
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ADAMDEC1 accelerates GBM progression via activation of the MMP2-related pathway
Frontiers in Oncology, 2022 The ADAM (a disintegrin and metalloprotease) gene-related family including ADAM, ADAMTS, and ADAM-like decysin-1 has been reported to play an important role in the pathogenesis of multiple diseases, including cancers (lung cancer, gliomas, colorectal ...
Huimin Qi +11 more
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Evolutionary divergence and functions of the
Human Genomics, 2009 The 'A-disintegrin and metalloproteinase' (ADAM) and 'A-disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) genes make up two similar, yet distinct, gene families.
Brocker Chad N +2 more
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Snake venom disintegrins update: insights about new findings [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2023 Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine, present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae, Elapidae, and Colubridae.
Gabriela de Oliveira Almeida +3 more
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Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni. [PDF]
PLoS Pathogens, 2017 Interactions between early developing Schistosoma mansoni larval stages and the hemolymph of its snail intermediate host represent the first molecular encounter with the snail's immune system.
Xiao-Jun Wu +7 more
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ADAM-15 Disintegrin-Like Domain Structure and Function
Toxins, 2010 The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu +3 more
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Role of hypoxia-related proteins in adenoid cystic carcinoma invasion
Diagnostic Pathology, 2020 Background Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity.
Raíssa Pinheiro de Mendonça +9 more
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ADAM and ADAMTS Proteases in Hepatic Disorders
Journal of Renal and Hepatic Disorders, 2019 Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the ...
Dirk Schmidt-Arras +2 more
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BMC Cancer, 2018 Background A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied
Xiaodong Jiao +6 more
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Toxins, 2023 A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai +6 more
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