Implication of ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 in Implantational Remodeling of a Mouse Uterus [PDF]
, 2006 In the present study, whether the ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 proteins might play a role in mouse uterus during periimplantation period was investigated.
Blankenship +44 more
core +2 more sources
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]
, 2005 Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
core +2 more sources
Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis [PDF]
, 2017 OBJECTIVE: The aggrecanase ADAMTS-5 and the collagenase matrix metalloproteinase 13 (MMP-13) are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low-density lipoprotein receptor-
Botkjaer, K A +7 more
core +4 more sources
Role of hypoxia-related proteins in adenoid cystic carcinoma invasion
Diagnostic Pathology, 2020 Background Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity.
Raíssa Pinheiro de Mendonça +9 more
doaj +1 more source
Toxins, 2023 A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai +6 more
doaj +1 more source
Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors [PDF]
, 2016 Autosomal dominant lateral temporal epilepsy (ADTLE) is a focal epilepsy syndrome caused by mutations in the LGI1 gene, which encodes a secreted protein.
Belluzzi, Elisa +7 more
core +3 more sources
Future therapeutic strategies: Implications for Brk targeting [PDF]
, 2011 The official published article can be found at the link below - Copyright @ 2011 InTech. This Article has been provided by the Brunel Open Access Publishing Fund.Rajpal Burmi was supported by a Breast Cancer Campaign project ...
Burmi, RS, Harvey, AJ
core +2 more sources
ADAM and ADAMTS Proteases in Hepatic Disorders
Journal of Renal and Hepatic Disorders, 2019 Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the ...
Dirk Schmidt-Arras +2 more
doaj +1 more source
Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]
PLoS ONE, 2016 The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi +10 more
doaj +1 more source
Membranes, 2022 A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang +7 more
doaj +1 more source