BMC Cancer, 2018 Background A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied
Xiaodong Jiao +6 more
doaj +1 more source
Toxins, 2023 A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai +6 more
doaj +1 more source
Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon [PDF]
, 2006 To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured ...
Alfredson +73 more
core +1 more source
Expression of ADAM‐9 mRNA and protein in human breast cancer [PDF]
International Journal of Cancer, 2003 AbstractThe ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance of ADAM‐9 in breast cancer.
O'Shea C +7 more
openaire +3 more sources
Detection of the ADAM proteins in the ejaculated bovine sperm
International journal of health sciences, 2022 The current study aimed to detect specific types of ADAM proteins in the bovine sperm. Histology study of tissue of male reproduction was involved with testis, head, body, and the tail of the epididymis. Results showed that the testis composed of the parenchyma of testis contained the seminiferous tubules which are surrounded by two layers externally ...
Asseel Yassin +2 more
openaire +1 more source
Membranes, 2022 A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang +7 more
doaj +1 more source
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. [PDF]
, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Daugherty, Matthew D +3 more
core +1 more source
Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]
PLoS ONE, 2016 The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi +10 more
doaj +1 more source
The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast [PDF]
, 2013 The ADP/ATP carrier protein (AAC) expressed in Artemia franciscana is refractory to bongkrekate. We generated two strains of Saccharomyces cerevisiae where AAC1 and AAC3 were inactivated and the AAC2 isoform was replaced with Artemia AAC containing a ...
A Keller +71 more
core +4 more sources
Superoxide reductase from Giardia intestinalis: structural characterization of the first sor from a eukaryotic organism shows an iron centre that is highly sensitive to photoreduction [PDF]
, 2015 Superoxide reductase (SOR), which is commonly found in prokaryotic organisms, affords protection from oxidative stress by reducing the superoxide anion to hydrogen peroxide.
Bandeiras, Tiago M. +8 more
core +2 more sources