Results 271 to 280 of about 10,772,271 (320)
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ADAM Proteins- Therapeutic Potential in Cancer
Current Cancer Drug Targets, 2008The A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin-superfamily of Zn-dependent metalloproteinases that shed the extracellular domains of membrane-bound growth factors, cytokines and their receptors. The latter play a central role in cell signaling and contribute a potential target in cancer therapy. Of particular interest are
Xinjie Lu, Mike Scully, Vijay Kakkar
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European Journal of Cell Biology, 2011 ADAM metalloproteases are membrane bound glycoproteins that control many biological processes during development and differentiation, mainly by acting as ectodomain sheddases. The Drosophila genome contains five genes that code for classical ADAM proteins which are characterized by a highly conserved domain structure with the respective catalytic ...
Maik Drechsler +2 more
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Altered cell‐matrix associated ADAM proteins in Alzheimer disease
Journal of Neuroscience Research, 2000 Alterations in cell-matrix 'contact' are often related to a disruption of cell cycle regulation and, as such, occur variously in neoplasia, Given the recent findings showing cell cycle alterations in Alzheimer disease, we undertook a study of ADAM-1 and ...
Jennifer L. Gerst +8 more
semanticscholar +5 more sources
ADAM proteins, their ligands, and clinical implications
Neurology, 2012AD= : Alzheimer disease; ADAM= : A disintegrin and metalloproteinase; ADEAF= : autosomal dominant partial epilepsy with auditory features; ADTLE= : autosomal dominant familial temporal lobe epilepsy; APP= : amyloid precursor protein; EPTP= : epitempin; Kv= : voltage-gated potassium; LGI= : leucine-rich, glioma inactivated; LRR= :
E. Benarroch
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Journal of Clinical Neuroscience, 2004
ADAM proteins are a family of metalloproteinases with a disintegrin domain. They have proteolytic as well as adhesive functions and can be involved in cell fusion events. Some ADAM proteins are expressed in a highly tissue restricted fashion, whereas others are expressed quite ubiquitously. In the brain, ADAM proteins have a role in neural development,
U. Novak
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ADAM proteins are a family of metalloproteinases with a disintegrin domain. They have proteolytic as well as adhesive functions and can be involved in cell fusion events. Some ADAM proteins are expressed in a highly tissue restricted fashion, whereas others are expressed quite ubiquitously. In the brain, ADAM proteins have a role in neural development,
U. Novak
semanticscholar +3 more sources
Sexual Selection and the Molecular Evolution of ADAM Proteins
Journal of Molecular Evolution, 2010Rapid evolution has been identified for many reproductive genes and recent studies have combined phylogenetic tests and information on species mating systems to test sexual selection. Here we examined the molecular evolution of the ADAM gene family, a diverse group of 35 proteins capable of adhesion to and cleavage of other proteins, using sequence ...
S. Finn, A. Civetta
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The Emerging Role of ADAM Metalloproteinases in Immunity
Nature Reviews Immunology, 2018Matthias Vanderkerken +2 more
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