Results 291 to 300 of about 10,772,271 (320)
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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
American Journal of Physiology-Cell Physiology, 2006A disintegrin and metalloprotease (ADAM) is a membrane-anchored metalloprotease implicated in the ectodomain shedding of cell surface proteins, including the ligands for epidermal growth factor (EGF) receptors (EGFR)/ErbB. It has been well documented that the transactivation of the EGFR plays critical roles for many cellular functions, such as ...
Haruhiko, Ohtsu +2 more
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Life Science, 2020
AIMS Epithelial-mesenchymal transition (EMT) is one of the important regulators of metastasis in advanced hepatocellular carcinoma (HCC). Blocking the Notch signaling pathway and then reversing the EMT process is a hot spot in clinical tumor research ...
Hong-Yuan Lu +8 more
semanticscholar +1 more source
AIMS Epithelial-mesenchymal transition (EMT) is one of the important regulators of metastasis in advanced hepatocellular carcinoma (HCC). Blocking the Notch signaling pathway and then reversing the EMT process is a hot spot in clinical tumor research ...
Hong-Yuan Lu +8 more
semanticscholar +1 more source
Snake venom metalloproteinases: Structure, function and relationship to the ADAMs family of proteins
Toxicon, 1996A large number of zinc metalloproteinases of varying mol. wts and biological functions has been isolated from crotalid and viperid venoms. Over the past few years, structural studies on these proteinases have suggested their organization into four classes, P-I to P-IV.
L G, Jia +3 more
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Protein synthesis during germination of Peronospora tabacina (Adam) conidia
Archives of Biochemistry and Biophysics, 1971The characteristics of an in vitro amino acid-incorporating system prepared from germinated Peronospora tabacina conidia are described. Material sedimenting at 20,000 g and at 117,000 g was found to possess significant amino acid-incorporating activity. Although germination is accompanied by an increase in the activity of both these fractions, if
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The ADAMs family of proteins: from basic studies to potential clinical applications
Thrombosis and Haemostasis, 2003SummaryThe ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease domain. Currently,34 members are known to exist. Approximately 50% of the ADAMs contain a metalloprotease-like domain and some of these have been shown to possess protease activity.
Michael J, Duffy +3 more
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Pharmacological Research, 2019
Acquired drug-resistant non-small cell lung cancer (NSCLC) has strong proliferation ability and is prone to epithelial-mesenchymal transition (EMT) and subsequent metastasis.
Hong-Yuan Lu +8 more
semanticscholar +1 more source
Acquired drug-resistant non-small cell lung cancer (NSCLC) has strong proliferation ability and is prone to epithelial-mesenchymal transition (EMT) and subsequent metastasis.
Hong-Yuan Lu +8 more
semanticscholar +1 more source
2003
Publisher Summary Since their discovery about a decade ago, some very intriguing insights into the function of a few Anchored Metalloprotease-Disintegrin Proteins (ADAMs) have emerged. They have been linked to a role in cell–cell interactions as potential integrin ligands and in the cleavage and release and, in several cases, activation of membrane ...
J David, Becherer, Carl P, Blobel
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Publisher Summary Since their discovery about a decade ago, some very intriguing insights into the function of a few Anchored Metalloprotease-Disintegrin Proteins (ADAMs) have emerged. They have been linked to a role in cell–cell interactions as potential integrin ligands and in the cleavage and release and, in several cases, activation of membrane ...
J David, Becherer, Carl P, Blobel
openaire +2 more sources
Donn Adam Gito: Exploring The Non-Classical Properties of Proteins
2023A group of proteins can generate electrical charges under applied stress, a functional property known as piezoelectricity. Although, the fundamentals of piezoelectricity are based on inorganic crystals and not on organic materials. Hence, there is ambiguity in the relationship between the structure of the proteins and their piezoelectric response.
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Inflammation Research, 2002
Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences by promoting diseases such as cancer, arthritis, and Alzheimer's disease.
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Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences by promoting diseases such as cancer, arthritis, and Alzheimer's disease.
openaire +2 more sources