Results 71 to 80 of about 182,768 (228)

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

Frontiers in Immunology, 2022
ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways.
Kai Wang, Zixue Xuan, Xiaoyan Liu, Meiling Zheng, Chao Yang, Haiyong Wang   +5 more
doaj   +1 more source

The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]

, 2015
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Adam Dyer, Albrecht, Bagos, Barcena-Uribarri, Behera, Bhide, Bordier, Brooks, Bunikis, Cabello, Casjens, Coutte, Crago, Crother, Cullen, Di, Dietrich, Eddy, Eswar, Fairman, Feng, Finn, Fraser, Freeman, Gemma Brown, Gessmann, Greene, Guina, Heffernan, Hong, Jaroszewski, Kenedy, Koebnik, Kopp, Kraiczy, Kurtenbach, Lenhart, Lenka Stejskal, Livengood, Margos, Mertins, Mittal, Nair, Oksi, Ornstein, Ostberg, Paetzel, Pautsch, Petersen, Peter R. Laity, Pettersen, Prasadarao, Preac-Mursic, Pugsley, Pulzova, Richard J. Bingham, Robert, Rogovskyy, Schmidli, Schulz, Setubal, Skare, Sperisen, Steere, Struyve, Sugawara, Svergun, Tamm, Thein, Tilly, Tommassen, Vogt, Volkov, Xie, Yamashita, Yang, Zhang   +76 more
core   +1 more source

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase [PDF]

Journal of Biological Chemistry, 2009
ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject to RIP.
Tousseyn, T, Thathiah, A, Jorissen, E, Raemaekers, T, Konietzko, U, Reiss, K, Maes, E, Snellinx, A, Serneels, L, Nyabi, O, Annaert, W, Saftig, P, Hartmann, D, De Strooper, B   +13 more
openaire   +2 more sources

Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model. [PDF]

, 2017
Importance: An overwhelming amount of data suggest that cardiovascular exercise has a positive effect on the mind and body, although the precise mechanism is not always clear.
Aksamitiene, Edita, Baker, Adam L., Hobelmann, Kealan, Hoek, Jan B., Hota, Salini, Pribitkin, Edmund A., Rodin, Julianna, Roy, Sudeep, Zhang, Li-Hui   +8 more
core   +3 more sources

Proteases at work: Cues for understanding neural development and degeneration

Frontiers in Molecular Neuroscience, 2015
Proteolytical processing of membrane bound molecules is a fundamental mechanism for the degradation of these proteins as well as for controlling cell-to-cell communication, which is at the basis of tissue development and homeostasis.
Paul eSaftig, Paola eBovolenta
doaj   +1 more source

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter, Bondong, Sandra, Gast, Daniela, Gutwein, Paul, Kiefel, Helena, Riedle, Svenja, Wolterink, Silke   +6 more
core  

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

γδ T LYMPHOCYTES AS A FIRST LINE OF IMMUNE DEFENSE: OLD AND NEW WAYS OF ANTIGEN RECOGNITION AND IMPLICATIONS FOR CANCER IMMUNOTHERAPY.

Frontiers in Immunology, 2014
Among γδT cells, the Vδ1 subset, resident in epithelial tissues, is implied in the defense against viruses, fungi and certain hematological malignancies, while the circulating Vδ2 subpopulation mainly respond to mycobacteria and solid tumors.
Maria Raffaella eZocchi, Alessandro ePoggi   +1 more
doaj   +1 more source

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. [PDF]

, 2009
BackgroundThe human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik, Adam, Istomin, Andrei Y
core   +4 more sources

Identification and preliminary characterization of mouse Adam33

BMC Genetics, 2002
Background The metalloprotease-disintegrin family, or ADAM, proteins, are implicated in cell-cell interactions, cell fusion, and cell signaling, and are widely distributed among metazoan phyla.
Hyman Richard W, Kim Philip H, Azarani Arezou, Gunn Teresa M, Davis Ronald W, Barsh Gregory S   +5 more
doaj   +1 more source