Results 81 to 90 of about 182,358 (311)

Differential Spatio-Temporal Regulation of MMPs in the 5xFAD Mouse Model of Alzheimer’s disease: Evidence for aPro-Amyloidogenic Role of MT1-MMP

Frontiers in Aging Neuroscience, 2014
Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of neurodegenerative/neuroinflammatory processes through their interactions with a large number of substrates.
Nathalie ePy, Amandine eBonnet, Anne eBernard, Yannick eMarchalant, Eliane eCharrat, Frédéric eChecler, Michel eKhrestchatisky, Kévin eBaranger, Santiago eRivera   +8 more
doaj   +1 more source

Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis [PDF]

, 2016
No abstract ...
Harvey, Adam, Lopes, Rheure A., Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian   +4 more
core   +2 more sources

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

HIF-1α is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1α and NOTCH1 Signaling Pathways

Cells, 2019
Background: The odontogenic keratocyst (OKC) is an odontogenic cyst that shows aggressive and intriguing biological behavior. It is suggested that a hypoxic environment occurs in OKC, which led us to investigate the immunoexpression and location of ...
Natacha Malu Miranda da Costa, Caio Tadashi Saab Abe, Geovanni Pereira Mitre, Ricardo Alves Mesquita, Maria Sueli da Silva Kataoka, André Luis Ribeiro Ribeiro, Ruy Gastaldoni Jaeger, Sérgio de Melo Alves-Júnior, Andrew Mark Smith, João de Jesus Viana Pinheiro   +9 more
doaj   +1 more source

Current approaches for modulation of the nanoscale interface in the regulation of cell behavior [PDF]

, 2018
Regulation of cell behavior in response to nanoscale features has been the focus of much research in recent years and the successful generation of nanoscale features capable of mimicking the natural nanoscale interface has been of great interest in the ...
Dalby, Matthew J., Donnelly, Hannah, Salmeron-Sanchez, Manuel, Sweeten, Paula E.   +3 more
core   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing

iScience
Summary: ADAM29 (a disintegrin and metalloprotease domain 29) is a member of the membrane-anchored ADAM family of proteins, which is highly expressed in testis and may mediate different physiological and pathological processes.
Diana Campos-Iglesias, Alejandro A. Montero, Francisco Rodríguez, Carlos López-Otín, José M.P. Freije   +4 more
doaj   +1 more source

RNAi-mediated knockdown of gut receptor-like genes prohibitin and α-amylase altered the susceptibility of Galleria mellonella to Cry1AcF toxin

BMC Genomics, 2022
Background Due to the prolonged usage of Bt-based biopesticides and Bt-transgenic crops worldwide, insects are continually developing resistance against Cry toxins.
Tushar K. Dutta, Abhishek Mandal, Artha Kundu, Victor Phani, Chetna Mathur, Arudhimath Veeresh, Rohini Sreevathsa   +6 more
doaj   +1 more source

Chronic tendon pathology: molecular basis and therapeutic implications [PDF]

, 2005
Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
core   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source