Results 81 to 90 of about 6,817,096 (349)

HIF-1α is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1α and NOTCH1 Signaling Pathways

open access: yesCells, 2019
Background: The odontogenic keratocyst (OKC) is an odontogenic cyst that shows aggressive and intriguing biological behavior. It is suggested that a hypoxic environment occurs in OKC, which led us to investigate the immunoexpression and location of ...
Natacha Malu Miranda da Costa   +9 more
doaj   +1 more source

Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells. [PDF]

open access: yesPLoS ONE, 2013
A disintegrin and metalloproteases (ADAMs) have been implicated in many processes controlling organismic development and integrity. Important substrates of ADAM proteases include growth factors, cytokines and their receptors and adhesion proteins.
Henriette Ebsen   +3 more
doaj   +1 more source

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

open access: yesFrontiers in Immunology, 2022
ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways.
Kai Wang   +5 more
doaj   +1 more source

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

open access: yesAdvanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang   +25 more
wiley   +1 more source

γδ T LYMPHOCYTES AS A FIRST LINE OF IMMUNE DEFENSE: OLD AND NEW WAYS OF ANTIGEN RECOGNITION AND IMPLICATIONS FOR CANCER IMMUNOTHERAPY.

open access: yesFrontiers in Immunology, 2014
Among γδT cells, the Vδ1 subset, resident in epithelial tissues, is implied in the defense against viruses, fungi and certain hematological malignancies, while the circulating Vδ2 subpopulation mainly respond to mycobacteria and solid tumors.
Maria Raffaella eZocchi   +1 more
doaj   +1 more source

Facile Fabrication of Large‐Area Biofunctionalized Metallic Nanostructures for High Performance Affinity Plasmonic Biosensors

open access: yesAdvanced Materials Technologies, EarlyView.
A novel approach enables facile and reproducible fabrication of gold nanoparticle arrays with tunable near‐infrared plasmonic properties and enhanced sensing accuracy. Using advanced lithography and ion milling, combined with innovative surface chemistry, the approach minimizes ohmic losses and non‐specific sorption, improving biomolecular detection ...
Dario Cattozzo Mor   +12 more
wiley   +1 more source

Proteases at work: Cues for understanding neural development and degeneration

open access: yesFrontiers in Molecular Neuroscience, 2015
Proteolytical processing of membrane bound molecules is a fundamental mechanism for the degradation of these proteins as well as for controlling cell-to-cell communication, which is at the basis of tissue development and homeostasis.
Paul eSaftig, Paola eBovolenta
doaj   +1 more source

Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics [PDF]

open access: yes, 2014
We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ).
Boyden, Edward S   +11 more
core  

Solvent‐ and Transition Metal‐Free Mechanochemical Synthesis of 2‐Thiazolines and S‐Thiocarbamates

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Solvent‐ and transition metal‐free synthetic pathways for obtaining 2‐thiazolines and S‐thiocarbamates, based on the mechanochemical process of addition of chloroalkyl iso(thio)cyanates to thiols catalyzed by cheap and commercially available K2CO3, are designed and optimized.
Kamil Hanek   +3 more
wiley   +1 more source

A Disintegrin and Metalloproteinase Protein 8 (ADAM 8) in Autism Spectrum Disorder: Links to Neuroinflammation

open access: yesNeuropsychiatric Disease and Treatment, 2023
Converging lines of evidence confirmed neuroinflammation's role in autism spectrum disorder (ASD) etiological pathway. A disintegrin and metalloproteinase 8 (ADAM8) play major roles in inflammatory and allergic processes in various diseases.This study aimed to investigate ADAM8 plasma levels in autistic children compared to healthy controls.
Laila Al-Ayadhi   +6 more
openaire   +3 more sources

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