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PO20 | DYSFUNCTION OF THE ADAMTS-13 / VON WILLEBRAND FACTOR AXIS, MEDIATED BY NETOSIS, AS A DRIVER OF PROTHROMBOTIC STATE AND UNFAVORABLE PROGNOSIS IN ONCOGYNECOLOGICAL PATIENTS

Bleeding, Thrombosis and Vascular Biology
Introduction. An imbalance between von Willebrand factor (VWF) and its primary protease, ADAMTS-13, plays a crucial role in the pathogenesis of microthrombosis and endotheliopathy.
Alexander Makatsariya
doaj  

von Willebrand factor, ADAMTS-13, and thrombospondin 1 in relation to clinical outcomes in elderly patients with a recent myocardial infarction. [PDF]

Res Pract Thromb Haemost, 2023
Warlo EMK, Kalstad AA, Myhre PL, Solheim S, Arnesen H, Tveit A, Holme PA, Seljeflot I, Bratseth V.   +8 more
europepmc   +1 more source

Incidence of thrombotic microangiopathies in Quebec: insight from a laboratory centralizing ADAMTS-13 testing. [PDF]

Orphanet J Rare Dis, 2022
Merlen C, Pépin E, Barry O, Cormier A, Dubois C, Lapeyraque AL, Troyanov S, Rivard GE, Bonnefoy A.   +8 more
europepmc   +1 more source

von Willebrand factor cleaving protease-ADAMTS 13. [PDF]

Haematologica
Scully M.
europepmc   +1 more source

Low ADAMTS-13/VWF ratio and altered gut-liver axis predict complications of advanced chronic liver disease: a pilot study. [PDF]

Gastroenterol Rep (Oxf), 2022
Ponziani FR, Sacco M, Tardugno M, Santopaolo F, Marsico A, Manna S, Lancellotti S, Gasbarrini A, De Cristofaro R, Pompili M.   +9 more
europepmc   +1 more source

ADAMTS-13 R1206K variant exhibits an open conformation and an enhanced proteolytic activity toward von Willebrand factor. [PDF]

J Thromb Haemost
Liu S, Dong X, Bonnez Q, Chai Z, Meng C, Gil M, Vanhoorelbeke K, Halkidis K, Zheng XL.   +8 more
europepmc   +1 more source

Congenital ADAMTS-13 deficiency presenting as life-threatening thrombosis during pregnancy. [PDF]

BMJ Case Rep, 2021
Hasan F, Gupta A, Chandra D, Nityanand S.   +3 more
europepmc   +1 more source

Dynamic Monitoring of ADAMTS-13 Activity for Differential Diagnosis Across the Spectrum of Sepsis-Associated Thrombotic Microangiopathies. [PDF]

Mediterr J Hematol Infect Dis
Liu Y, Lu F, Ji B, Song W, Shen H, Xu Y, Yang B.   +6 more
europepmc   +1 more source

ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy. [PDF]

Bioengineered, 2021
Meng X, Huang W, Mo W, Shu T, Yang H, Ning H.   +5 more
europepmc   +1 more source

Quantification of von Willebrand factor and ADAMTS-13 after traumatic injury: a pilot study. [PDF]

Trauma Surg Acute Care Open, 2021
MacArthur TA, Goswami J, Moon Tasson L, Tischer A, Bailey KR, Spears GM, Dong JF, Auton M, Kozar R, Park MS.   +9 more
europepmc   +1 more source